Bioequivalence and Bioavailability Forum • BQL rules in bear

BQL rules in bear [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2016-02-02 11:59 (2998 d 11:41 ago) – Posting: # 15915
Views: 24,419

Dear mittyri,

Yes, I have already taken your example dataset into consideration since last Astea's message. That's why I am still thinking how to fix it once for all. The situation is possible for delayed oral absorption (there is a T_lag), though I still wonder how to make sure if it is due to a delayed absorption or it is a true BLOQ (as we have had a lot of discussions at this Forum). Anyway, the time of first data point with conc. = 0 is critical for AUC calculation.

❝ What about more tricky datasets?

❝ Data set: "subj","seq","prd","time","conc"

❝ 1,2,2,0,0

❝ 1,2,2,0.25,0

❝ 1,2,2,0.5,0

❝ 1,2,2,0.75,1

❝ [...]

❝ I think you are close enough to pre-processing of datasets (as in PHX - BQL rules, I can send you PDF guide if needed, there are some examples of rules), so the users can define their own rules of data handling (missing, BLOQ depending on position of data).

Thank you so much for your kindness. But that won't be necessary.

—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

bear v2.7.0 released yjlee168 2015-12-07 09:18 [🇷 for BE/BA]
- Suggestion ElMaestro 2015-12-07 10:12
  - Suggestion yjlee168 2015-12-07 10:55
    - Suggestion Helmut 2015-12-07 14:01
      - Suggestion yjlee168 2015-12-07 18:51
- bear v2.7.0 released Astea 2015-12-10 16:36
  - if Clast is zero in bear yjlee168 2015-12-10 17:23
    - if Clast is zero in bear Astea 2015-12-10 20:50
      - if Clast is zero in bear yjlee168 2015-12-11 03:28
        
        if Clast is zero in bear Astea 2015-12-11 09:39
        
        if Clast is zero in bear yjlee168 2015-12-11 17:16
    - bear v2.7.1 yjlee168 2015-12-15 10:21
      - bear v2.7.1 Astea 2015-12-15 19:32
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
        
        BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
        
        BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
        
        BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
        
        BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
        
        zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
        
        BQL rules in bear mittyri 2016-02-01 22:16
        
        BQL rules in bearyjlee168 2016-02-02 10:59
        possible solutions? yjlee168 2016-02-02 21:30
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
        
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
        
        Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
        
        error message in bear mahmoud-teaima 2016-02-09 04:55
        
        please check your dataset file yjlee168 2016-02-09 06:40
        
        please check your dataset file mahmoud-teaima 2016-02-09 15:00
        
        please check your dataset file yjlee168 2016-02-09 15:38
        
        A possible R bug? yjlee168 2016-02-09 19:14