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Registerrandom effect, fix effect in the guidance Appendix E [Regulatives / Guidelines]
Hallo LS,
Only SAS knows (The power to know)
.
This is an example of the silly and somewhat counter-intuitive syntax of PROC MIXED. The key is the /Sub=subj part in the random statement.
This defines a random subject effect within each TRT, i.e. the random subject effects are assumed different for treatment groups in the study. So you can have different variabilities for test and reference products.
If you need some deeper and more elaborate text about models and evaluation of replicate cross-over designs have a look at
Scott D Patterson and Byron Jones
REPLICATE DESIGNS AND AVERAGE, INDIVIDUAL, AND
POPULATION BIOEQUIVALENCE
GSK BDS Technical Report 2002 – 01
Can be found in the net of nets
http://biometrics.com/wp-content/uploads/2009/06/tr2002-01.pdf
--
Edit: Updated URL. [Helmut]
❝ Does anybody know which why TRT is written in random effect and also in fixed effect. Why TRT is random effect? What description is correct to address statistical method from the above code
Only SAS knows (The power to know)
.This is an example of the silly and somewhat counter-intuitive syntax of PROC MIXED. The key is the /Sub=subj part in the random statement.
This defines a random subject effect within each TRT, i.e. the random subject effects are assumed different for treatment groups in the study. So you can have different variabilities for test and reference products.
If you need some deeper and more elaborate text about models and evaluation of replicate cross-over designs have a look at
Scott D Patterson and Byron Jones
REPLICATE DESIGNS AND AVERAGE, INDIVIDUAL, AND
POPULATION BIOEQUIVALENCE
GSK BDS Technical Report 2002 – 01
Can be found in the net of nets
http://biometrics.com/wp-content/uploads/2009/06/tr2002-01.pdf
--
Edit: Updated URL. [Helmut]
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- random effect, fix effect in the guidance Appendix E LS 2008-02-05 18:53 [Regulatives / Guidelines]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- random effect, fix effect in the guidance Appendix Ed_labes 2008-02-06 13:34
- random effect, fix effect in the guidance Appendix E LS 2008-02-06 17:58
- random effect, fix effect in the guidance Appendix E d_labes 2008-02-07 10:14
- random effect, fix effect in the guidance Appendix E SKR 2008-03-06 10:54
- Satterthwaite degrees of freedom Helmut 2008-03-06 13:57
- Satterthwaite degrees of freedom d_labes 2008-03-10 09:59
- Satterthwaite DF; SAS Helmut 2008-03-10 12:24
- Satterthwaite DF; SAS d_labes 2008-03-10 14:50
- Satterthwaite DF; SAS mathews 2008-03-11 07:12
- SAS Proc Mixed coding, replicate design d_labes 2008-03-11 09:43
- SAS Proc Mixed coding, replicate design Sathya 2008-09-17 07:21
- Replicate design evaluation d_labes 2008-09-17 10:49
- Replicate design evaluation Sathya 2008-09-18 06:43
- Replicate design evaluation d_labes 2008-09-17 10:49
- SAS Proc Mixed coding, replicate design Sathya 2008-09-17 07:21
- SAS Proc Mixed coding, replicate design d_labes 2008-03-11 09:43
- Satterthwaite DF; SAS mathews 2008-03-11 07:12
- Satterthwaite DF; SAS d_labes 2008-03-10 14:50
- Satterthwaite DF; SAS Helmut 2008-03-10 12:24
- Satterthwaite degrees of freedom d_labes 2008-03-10 09:59
- Satterthwaite degrees of freedom Helmut 2008-03-06 13:57
- random effect, fix effect in the guidance Appendix E SKR 2008-03-06 10:54
- random effect, fix effect in the guidance Appendix E d_labes 2008-02-07 10:14
- random effect, fix effect in the guidance Appendix E LS 2008-02-06 17:58
- random effect, fix effect in the guidance Appendix Ed_labes 2008-02-06 13:34
Ing. Helmut Schütz