Protocol [Off Topic]

posted by nobody – 2016-01-28 16:40 (3305 d 18:31 ago) – Posting: # 15883
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"Half-life (persistence in the blood) of the drug in rats was 45 hours (oral) or 4 hours (i.v.) and in dogs it was 104 hours (oral) or 52 hours (i.v.)." Wikipedia, from protocol, p. 28

WOW! Values given for total radioactivity... apparently oral dosing results in some long-lasting metabolite?


"In the mouse, rat, dog and monkey, BIA 10-2474 undergoes extensive metabolism" ibid

Interesting. Details would be nice. Even on human microsomes and other in vitro stuff...


Experience in humans before this trial according to protocol: zero, null, niente.

Kindest regards, nobody

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