Bioequivalence and Bioavailability Forum

target power 90% [🇷 for BE/BA]

posted by Helmut  – Vienna, Austria, 2016-01-28 14:49 (3441 d 21:16 ago) – Posting: # 15879
Views: 18,080

Dear Shuanghe and Detlew,

❝ I also noticed similar effect when I was playing sample size for power of 90%, without the wonder code like Helmut's of course

Target power 90%:



@Detlew: In my code I had to arbitrarily increase nstart in the second attempt, i.e., to

x <- sampleN.RSABE(CV=CV[j], theta0=GMR[k], targetpower=0.9,
                   design="2x2x4", print=FALSE,
                   details=FALSE, nstart=x[["nlast"]]*1.5)

because for CV=0.305, theta0=0.82 nlast is 442. With nstart=nlast the algo stops again (n 644, power 0.89243). Currently in line 159 of the source-code imax is fixed with 100. What do you think about introducing imax as an argument like in sampleN.TOST()?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• PowerTOST sample size FDA full replicate T/R ratio at 85% Shuanghe 2016-01-25 17:49 [🇷 for BE/BA] 
  • PowerTOST sample size FDA full replicate T/R ratio at 85% d_labes 2016-01-26 12:05
    • PowerTOST sample size FDA full replicate T/R ratio at 85% Shuanghe 2016-01-26 12:55
      • PowerTOST sample size FDA full replicate T/R ratio at 85% d_labes 2016-01-26 14:07
      • maximum sample size at which CV? Helmut 2016-01-26 16:31
        • maximum sample size at which CV? nobody 2016-01-26 17:40
        • maximum sample size at which CV? d_labes 2016-01-27 08:41
          • maximum sample size at which CV? nobody 2016-01-27 09:08
            • OT: Stop - think -act d_labes 2016-01-27 09:31
        • maximum sample size at which CV? Shuanghe 2016-01-28 12:44
          • target power 90%Helmut 2016-01-28 13:49
            • PowerTOST update d_labes 2016-02-01 19:16
              • #1,000 Helmut 2016-02-01 21:49
                • OT: post #1,000 d_labes 2016-02-02 21:17
                • #1,000 ElMaestro 2016-02-03 16:32
                  • #1,000 Helmut 2016-02-03 16:50
                  • OT: #1,000 d_labes 2016-02-05 15:50
                    • OT: #1,000 ElMaestro 2016-02-05 17:02
                      • OT: #1,000 d_labes 2016-02-05 19:48
                        • OT: #1,000 ElMaestro 2016-02-06 15:45
                          • OT: #1,000 nobody 2016-02-07 09:50