PowerTOST sample size FDA full replicate T/R ratio at 85% [🇷 for BE/BA]
❝ "Not widened yet" is the false. ...
❝
❝ So far so good. This doesn't imply that at CV=30% the sample size is highest since we have the point estimate constraint in effect. This leads to the shift of the maximum sample size downwards of 30%.
Understood until here.
❝ This is also the case for your calculations with theta0=0.9, but not so pronounced seen as with theta0=0.85. Check it by power calculations with n=120 for theta0=0.85 or theta0=0.9 and n=32. You will find the minimum (implying max. sample size) below CV=30% in both cases.
Confused by this part.

❝ The why is not so easy to answer. ... My suggestion: Take the observed effect as is .
I think I'll just take what it is as you said. Much easier this way

❝ Of course not! Even the suspicion is an injury !
❝ It must be correct because PowerTOST says so .


All the best,
Shuanghe
Complete thread:
- PowerTOST sample size FDA full replicate T/R ratio at 85% Shuanghe 2016-01-25 17:49 [🇷 for BE/BA]
- PowerTOST sample size FDA full replicate T/R ratio at 85% d_labes 2016-01-26 12:05
- PowerTOST sample size FDA full replicate T/R ratio at 85%Shuanghe 2016-01-26 12:55
- PowerTOST sample size FDA full replicate T/R ratio at 85% d_labes 2016-01-26 14:07
- maximum sample size at which CV? Helmut 2016-01-26 16:31
- maximum sample size at which CV? nobody 2016-01-26 17:40
- maximum sample size at which CV? d_labes 2016-01-27 08:41
- maximum sample size at which CV? nobody 2016-01-27 09:08
- OT: Stop - think -act d_labes 2016-01-27 09:31
- maximum sample size at which CV? nobody 2016-01-27 09:08
- maximum sample size at which CV? Shuanghe 2016-01-28 12:44
- target power 90% Helmut 2016-01-28 13:49
- PowerTOST update d_labes 2016-02-01 19:16
- #1,000 Helmut 2016-02-01 21:49
- OT: post #1,000 d_labes 2016-02-02 21:17
- #1,000 ElMaestro 2016-02-03 16:32
- #1,000 Helmut 2016-02-03 16:50
- OT: #1,000 d_labes 2016-02-05 15:50
- OT: #1,000 ElMaestro 2016-02-05 17:02
- OT: #1,000 d_labes 2016-02-05 19:48
- OT: #1,000 ElMaestro 2016-02-06 15:45
- OT: #1,000 nobody 2016-02-07 09:50
- OT: #1,000 ElMaestro 2016-02-06 15:45
- OT: #1,000 d_labes 2016-02-05 19:48
- OT: #1,000 ElMaestro 2016-02-05 17:02
- #1,000 Helmut 2016-02-01 21:49
- PowerTOST update d_labes 2016-02-01 19:16
- target power 90% Helmut 2016-01-28 13:49
- PowerTOST sample size FDA full replicate T/R ratio at 85%Shuanghe 2016-01-26 12:55
- PowerTOST sample size FDA full replicate T/R ratio at 85% d_labes 2016-01-26 12:05