PowerTOST sample size FDA full replicate T/R ratio at 85% [🇷 for BE/BA]

posted by Shuanghe  – Spain, 2016-01-26 13:55 (3302 d 05:22 ago) – Posting: # 15854
Views: 17,659

Many thanks Detlew!

❝ "Not widened yet" is the false. ...


❝ So far so good. This doesn't imply that at CV=30% the sample size is highest since we have the point estimate constraint in effect. This leads to the shift of the maximum sample size downwards of 30%.


Understood until here.

❝ This is also the case for your calculations with theta0=0.9, but not so pronounced seen as with theta0=0.85. Check it by power calculations with n=120 for theta0=0.85 or theta0=0.9 and n=32. You will find the minimum (implying max. sample size) below CV=30% in both cases.


Confused by this part. :confused:

❝ The why is not so easy to answer. ... My suggestion: Take the observed effect as is :cool:.


I think I'll just take what it is as you said. Much easier this way :-D

❝ Of course not! Even the suspicion is an injury :-D!

❝ It must be correct because PowerTOST says so :cool:.


:ok: :clap:

All the best,
Shuanghe

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