λz from two points? [🇷 for BE/BA]
Hi Rabbaska,
❝ 0.5 0.27
❝ 1.0 0.36
❝ 2.0 0.42
❝ 3.0 0.60
❝ 4.0 0.70
❝ 6.0 0.49
Your Cmax is at four hours and you have only one descending concentration. Even if you would have sampled longer, it is debatable* whether the concentration at six hours should be used (might still be influenced by absorption/distribution).
What does you protocol say? Generally at least three samples are required. Up to you.
The latter.
Not with the default setting. Of course he/she could have forced PHX to use the last two time points, but
❝ time conc
❝ 0.5 0.27
❝ 1.0 0.36
❝ 2.0 0.42
❝ 3.0 0.60
❝ 4.0 0.70
❝ 6.0 0.49
Your Cmax is at four hours and you have only one descending concentration. Even if you would have sampled longer, it is debatable* whether the concentration at six hours should be used (might still be influenced by absorption/distribution).
bear
requires at least three data points to estimate λz. ❝ … and what to do with it?
What does you protocol say? Generally at least three samples are required. Up to you.
❝ Is it something with file (I tried to upload the same data with .RData, .csv, .txt and other formats, all in vane) or bear does not like the data?
The latter.
❝ For sure, my friend performed the analysis in Phoenix and had the result.
Not with the default setting. Of course he/she could have forced PHX to use the last two time points, but
- IMHO, it does not make sense.
- Would you prefer to report an extrapolated AUC which is 48% of AUC∞?
- Scheerans C, Derendorf H, Kloft C. Proposal for a Standardised Identification of the Mono-Exponential Terminal Phase for Orally Administered Drugs. Biopharm Drug Dispos. 2008;29(3):145–57.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Error with NCA calculation Rabbaska 2016-01-19 11:53 [🇷 for BE/BA]
- λz from two points?Helmut 2016-01-19 13:16