Death in phase I cannabinoid? [Off Topic]

posted by Helmut Homepage – Vienna, Austria, 2016-01-15 18:25 (3314 d 05:20 ago) – Posting: # 15830
Views: 43,805

Hi nobody,

❝ Any details available from serious sources on this:

https://news.yahoo.com/one-person-brain-dead-five-hospitalised-french-drug-104040442.html


Nope. That’s bizarre. Oral cannabinoids could never act as “painkillers” (fast acting) due to their low absorption, and extensive pre-systemic + first-pass metabolism. A few oral formulations were developed in the indication neuropathic pain but AFAIK none of them made it to approval so far. Would be interesting which cannabinoid was tested. Can’t imagine such shit [sic] happening with Δ9-THC (dronabinol) or cannabdiol.

Wait a minute.
http://www.independent.co.uk/news/world/europe/france-clinical-trial-one-person-brain-dead-and-five-more-in-hospital-after-drug-testing-a6813791.html
“Marisol Touraine, the French health minister, later said that the pill did not contain cannabis or its derivatives but acted on the body’s endocannabinoid system.”

Hhm.

The official press-release is not helpful. If you know French:
http://www.ouest-france.fr/bretagne/rennes-35000/essai-therapeutique-rennes-un-patient-en-etat-de-mort-clinique-3972041

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