Death in phase I cannabinoid? [Off Topic]
Hi nobody,
Nope. That’s bizarre. Oral cannabinoids could never act as “painkillers” (fast acting) due to their low absorption, and extensive pre-systemic + first-pass metabolism. A few oral formulations were developed in the indication neuropathic pain but AFAIK none of them made it to approval so far. Would be interesting which cannabinoid was tested. Can’t imagine such shit [sic] happening with Δ9-THC (dronabinol) or cannabdiol.
Wait a minute.
http://www.independent.co.uk/news/world/europe/france-clinical-trial-one-person-brain-dead-and-five-more-in-hospital-after-drug-testing-a6813791.html
“Marisol Touraine, the French health minister, later said that the pill did not contain cannabis or its derivatives but acted on the body’s endocannabinoid system.”
Hhm.
The official press-release is not helpful. If you know French:
http://www.ouest-france.fr/bretagne/rennes-35000/essai-therapeutique-rennes-un-patient-en-etat-de-mort-clinique-3972041
❝ Any details available from serious sources on this:
❝ https://news.yahoo.com/one-person-brain-dead-five-hospitalised-french-drug-104040442.html
Nope. That’s bizarre. Oral cannabinoids could never act as “painkillers” (fast acting) due to their low absorption, and extensive pre-systemic + first-pass metabolism. A few oral formulations were developed in the indication neuropathic pain but AFAIK none of them made it to approval so far. Would be interesting which cannabinoid was tested. Can’t imagine such shit [sic] happening with Δ9-THC (dronabinol) or cannabdiol.
Wait a minute.
http://www.independent.co.uk/news/world/europe/france-clinical-trial-one-person-brain-dead-and-five-more-in-hospital-after-drug-testing-a6813791.html
“Marisol Touraine, the French health minister, later said that the pill did not contain cannabis or its derivatives but acted on the body’s endocannabinoid system.”
Hhm.
The official press-release is not helpful. If you know French:
http://www.ouest-france.fr/bretagne/rennes-35000/essai-therapeutique-rennes-un-patient-en-etat-de-mort-clinique-3972041
—
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
- Death in phase I cannabinoid? nobody 2016-01-15 16:49 [Off Topic]
- Death in phase I cannabinoid?Helmut 2016-01-15 17:25
- Death in phase I cannabinoid? nobody 2016-01-15 17:45
- Death in phase I cannabinoid? Helmut 2016-01-15 17:48
- Death in phase I cannabinoid? nobody 2016-01-15 18:02
- Structure Ohlbe 2016-01-18 13:42
- Structure nobody 2016-01-28 15:29
- Death in phase I cannabinoid? Helmut 2016-01-15 17:48
- Death in phase I cannabinoid? Ohlbe 2016-01-18 09:58
- Death in phase I cannabinoid? nobody 2016-01-18 15:07
- Death in phase I cannabinoid? nobody 2016-01-15 17:45
- Protocol Ohlbe 2016-01-22 17:18
- Protocol nobody 2016-01-23 18:37
- Protocol Ohlbe 2016-01-28 12:16
- Protocol ElMaestro 2016-01-28 15:07
- Protocol nobody 2016-01-28 15:40
- FIM / FIH Helmut 2016-01-28 17:10
- FIM / FIH nobody 2016-01-28 17:55
- There is something rotten in the state... nobody 2016-02-26 21:05
- Rotten or not rotten ? Ohlbe 2016-02-27 05:49
- Rotten or not rotten ? nobody 2016-02-27 10:56
- Rotten or not rotten ? Ohlbe 2016-02-27 14:00
- Rotten.. nobody 2016-04-25 17:21
- Blame game... nobody 2016-05-23 12:27
- FDA: "unique toxiciy" nobody 2016-08-15 16:38
- Blame game... nobody 2016-05-23 12:27
- Rotten.. nobody 2016-04-25 17:21
- Rotten or not rotten ? Ohlbe 2016-02-27 14:00
- Rotten or not rotten ? nobody 2016-02-27 10:56
- Rotten or not rotten ? Ohlbe 2016-02-27 05:49
- There is something rotten in the state... nobody 2016-02-26 21:05
- FIM / FIH nobody 2016-01-28 17:55
- FIM / FIH Helmut 2016-01-28 17:10
- Protocol nobody 2016-01-28 15:40
- Chronology - English version Ohlbe 2016-01-29 18:30
- Chronology - English version Helmut 2016-01-29 19:04
- Administrative inspection preliminary outcome Ohlbe 2016-02-04 23:30
- Chronology - English version Helmut 2016-01-29 19:04
- Protocol ElMaestro 2016-01-28 15:07
- Protocol Ohlbe 2016-01-28 12:16
- Protocol nobody 2016-01-23 18:37
- Re-consenting volunteers? ElMaestro 2016-06-21 16:42
- Re-consenting volunteers? Ohlbe 2016-06-22 05:06
- Re-consenting volunteers? nobody 2016-06-22 11:26
- Re-consenting volunteers? Ohlbe 2016-06-23 04:51
- Re-consenting volunteers? ElMaestro 2016-06-23 08:23
- Re-consenting volunteers? nobody 2016-06-23 10:36
- OT: strike d_labes 2016-06-23 11:31
- OT: strike Helmut 2016-06-23 13:01
- Re-consenting volunteers? ElMaestro 2016-06-23 08:23
- Re-consenting volunteers? Ohlbe 2016-06-23 04:51
- Re-consenting volunteers? nobody 2016-06-22 11:26
- Re-consenting volunteers? Ohlbe 2016-06-22 05:06
- Paper in the NEJM Ohlbe 2016-11-03 12:21
- Death in phase I cannabinoid? nobody 2017-06-09 10:01
- Death in phase I cannabinoid?Helmut 2016-01-15 17:25