Power for PE outside the acceptance range [Power / Sample Size]
Dear Jay,
Simple enough: PE for AUC not outside acceptance range.
For Cmax with PE outside acceptance range you could even have a very large number of subjects in your study without rising your post-hoc power:
On the contrary power is even decreasing.
The post-hoc power is useless because it is a 1:1 function of the BE test.
(Count up: post 992)
Edit:
❝ ... But what may be the probable reason for such huge difference between post hoc power of Cmax and AUC.
Simple enough: PE for AUC not outside acceptance range.
For Cmax with PE outside acceptance range you could even have a very large number of subjects in your study without rising your post-hoc power:
library(PowerTOST)
power.TOST(CV=0.2101, theta0=1.278, n=18, design="2x3x3")
[1] 0.02239529
power.TOST(CV=0.2101, theta0=1.278, n=102, design="2x3x3")
[1] 0.005853529
power.TOST(CV=0.2101, theta0=1.278, n=1002, design="2x3x3")
[1] 5.443279e-06
On the contrary power is even decreasing.
The post-hoc power is useless because it is a 1:1 function of the BE test.
- BE for AUCt, AUCinf proven
- BE for Cmax not proven
(Count up: post 992)
Edit:
power.TOST()
calls changed to partial replicate design after Helmut's post below—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Post hoc Power Jay 2016-01-08 06:49 [Power / Sample Size]
- Post hoc Power ElMaestro 2016-01-08 15:07
- Post hoc Power Helmut 2016-01-09 14:21
- Post hoc Power Jay 2016-01-11 10:59
- PE outside the acceptance range Helmut 2016-01-11 14:02
- PE outside the acceptance range Jay 2016-01-13 08:24
- Power for PE outside the acceptance ranged_labes 2016-01-13 11:59
- PE at border of the AR: power ≡ 0.05 Helmut 2016-01-13 12:38
- PE at border of the AR: power ≡ 0.05 ? d_labes 2016-01-13 13:21
- PE at border of the AR: power ≤0.05! Helmut 2016-01-14 01:29
- UMP - uniformly more powerful test d_labes 2016-01-15 20:08
- PE at border of the AR: power ≤0.05! zizou 2016-01-24 22:12
- Smoothing artifact Helmut 2016-01-25 14:15
- PE at border of the AR: power ≤0.05! Helmut 2016-01-14 01:29
- PE at border of the AR: power ≡ 0.05 ? d_labes 2016-01-13 13:21
- PE outside the acceptance range Jay 2016-01-13 08:24
- PE outside the acceptance range Helmut 2016-01-11 14:02
- Post hoc Power Jay 2016-01-11 10:59