EOD [Software]

posted by Helmut Homepage – Vienna, Austria, 2016-01-11 23:13 (3316 d 06:22 ago) – Posting: # 15815
Views: 16,633

Hi G.C.,

❝ For one dose duration response study we have calculated ED50 and Emax by population model using Phoenix® NLME™ and we got below results.

❝ ED50 : 120

❝ Emax : -35

❝ On other hand, using PPHARM software the values are as below,

❝ ED50 : 50

❝ Emax : -26


You are responsible for validating your software in your computing environment, not I. I don’t know P-Pharm. Since it disagrees with PHX/NLME already at the first (!) significant digit, I guess it’s crap.
Have a look at the NIST’s reference datasets. The certified results were obtained in 128bit precision. The NIST considers an estimate obtained by other software acceptable if >4 significant digits match the certified result. I can only say, that my installation (Phoenix 6.4.0.768 / NLME 1.3 64bit) on my machine (Xeon E3-1245v3 Haswell 4×3.4GHz / 16GB RAM) with my OS (64bit Win7 SP1 all patches) gives for most datasets matches of 5–7 significant digits already with the first set of start values (sometimes even better with the second).
Do your homework.

This conversation leads to nowhere. EOD from my side. Thread closed.

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