Bioequivalence and Bioavailability Forum • Emax and ED50: NLME

Emax and ED50: NLME [Software]

posted by Helmut – Vienna, Austria, 2015-12-29 20:36 (3475 d 17:20 ago) – Posting: # 15779
Views: 18,678

Hi G.C.,

❝ Already I have registered Certara’s forum and sent same data but value does not matched with FDA guideline.

Please give a definition of “matching” – what did you expect to achieve? The FDA fitted only the means. Don’t know why you want to deal with a Population model. Below a comparison:

Emax ED50 FDA -48.8 1.89 WNL 101 -39.811 1.143 PHX/NLME -39.764 1.139 R/nls -39.764 1.139 XLS/solver -39.764 1.139 Gnumeric/NL -39.764 1.139

Do you see a pattern?

[image]

Given the close results obtained in other software, I would say you should not even try to “match” the FDA’s crappy results.

Nonlinear mixed-effects modeling… The recipe is a mixture of science, experience, luck, and art. The finished product sometimes is inedible. I think that the FDA’s results are crap. Not only the poor fit, but already the squeezed model. I’m able to come up with similar crap in PHX/NLME as well.

Emax ED50 Naive pooled -39.765 1.139 FOCE L-B -62.615 3.429

IMHO, with the given data (and an obsolete software nobody could explore) hoping for a “match” is futile.

[image]

Tortured data will confess to anything. Fredric E. Menger

The combination of some data and an aching desire
for an answer does not ensure that a reasonable answer
can be extracted from a given body of data. John W. Tukey

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Thread locked

Complete thread:

Emax and ED50: NLME gcpatel126 2015-12-09 18:08 [Software]
- Emax and ED50: NLME Helmut 2015-12-10 02:09
  - Emax and ED50: NLME gcpatel126 2015-12-10 17:34
    - Emax and ED50: NLME SDavis 2015-12-15 11:50
      - Emax and ED50: NLME gcpatel126 2015-12-29 15:49
        
        Emax and ED50: NLME Helmut 2015-12-29 17:46
        
        Emax and ED50: NLME gcpatel126 2015-12-29 18:04
        
        Emax and ED50: NLMEHelmut 2015-12-29 19:36
        
        Emax and ED50: NLME gcpatel126 2015-12-30 14:43
        
        Emax and ED50: NLME Helmut 2015-12-30 14:56
        
        Emax and ED50: NLME gcpatel126 2015-12-30 15:19
        
        Validation? Helmut 2015-12-30 16:02
        
        Validation? gcpatel126 2015-12-30 17:47
        
        Validation? Helmut 2015-12-30 21:15
        
        Validation? gcpatel126 2015-12-31 07:06
        
        Validation? gcpatel126 2016-01-11 14:54
        
        EOD Helmut 2016-01-11 22:13