Emax and ED50: NLME [Software]
Hi G.C.,
These data smell of FDA’s 1995 (!) Guidance on topical corticosteroids, Table AIII.4… Software: P-Pharm (Simed, France). ED50 1.89 h, Emax –48.8 h. The software doesn’t exist any more, the developer went out of business, the FDA didn’t give any details (fitting algo, weighting, constraints, …). Do you really expect that anybody without a time-machine will be able to reproduce these numbers? Was the fitted line drawn by someone with shaky hands or did the software spit it out?
These nice bars are standard errors – not standard deviations, aka cheating with statistics. At 0.75 hours the mean is –17.7 and the SD 21.4. Agreed, the SE with 6.2 looks better. The CVs range from 60 – 250%. Did you look at the individual data?
BTW, addressing Simon here is not a splendid idea. He passes by about once a month in his spare time. I hope for him that he is enjoying a Christmas / New Year vacation. Why didn’t you register at Certara’s forum and upload something there – as Simon and I suggested – instead of posting a data-cemetery full of tabs nobody could copy/paste? Please read Eric Raymond’s essay How To Ask Questions The Smart Way.
I’m half tempted to close this thread.
❝ Please find below FDA guideline data for calculation ED50 and Emax using nonlinear mixed effect model (population model). Please let me know value matches with guideline or not.
These data smell of FDA’s 1995 (!) Guidance on topical corticosteroids, Table AIII.4… Software: P-Pharm (Simed, France). ED50 1.89 h, Emax –48.8 h. The software doesn’t exist any more, the developer went out of business, the FDA didn’t give any details (fitting algo, weighting, constraints, …). Do you really expect that anybody without a time-machine will be able to reproduce these numbers? Was the fitted line drawn by someone with shaky hands or did the software spit it out?
These nice bars are standard errors – not standard deviations, aka cheating with statistics. At 0.75 hours the mean is –17.7 and the SD 21.4. Agreed, the SE with 6.2 looks better. The CVs range from 60 – 250%. Did you look at the individual data?
BTW, addressing Simon here is not a splendid idea. He passes by about once a month in his spare time. I hope for him that he is enjoying a Christmas / New Year vacation. Why didn’t you register at Certara’s forum and upload something there – as Simon and I suggested – instead of posting a data-cemetery full of tabs nobody could copy/paste? Please read Eric Raymond’s essay How To Ask Questions The Smart Way.
I’m half tempted to close this thread.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:
- Emax and ED50: NLME gcpatel126 2015-12-09 18:08 [Software]
- Emax and ED50: NLME Helmut 2015-12-10 02:09
- Emax and ED50: NLME gcpatel126 2015-12-10 17:34
- Emax and ED50: NLME SDavis 2015-12-15 11:50
- Emax and ED50: NLME gcpatel126 2015-12-29 15:49
- Emax and ED50: NLMEHelmut 2015-12-29 17:46
- Emax and ED50: NLME gcpatel126 2015-12-29 18:04
- Emax and ED50: NLME Helmut 2015-12-29 19:36
- Emax and ED50: NLME gcpatel126 2015-12-30 14:43
- Emax and ED50: NLME Helmut 2015-12-30 14:56
- Emax and ED50: NLME gcpatel126 2015-12-30 15:19
- Validation? Helmut 2015-12-30 16:02
- Validation? gcpatel126 2015-12-30 17:47
- Validation? Helmut 2015-12-30 21:15
- Validation? gcpatel126 2015-12-31 07:06
- Validation? gcpatel126 2016-01-11 14:54
- EOD Helmut 2016-01-11 22:13
- Validation? gcpatel126 2016-01-11 14:54
- Validation? gcpatel126 2015-12-31 07:06
- Validation? Helmut 2015-12-30 21:15
- Validation? gcpatel126 2015-12-30 17:47
- Validation? Helmut 2015-12-30 16:02
- Emax and ED50: NLME gcpatel126 2015-12-30 15:19
- Emax and ED50: NLME Helmut 2015-12-30 14:56
- Emax and ED50: NLME gcpatel126 2015-12-30 14:43
- Emax and ED50: NLME Helmut 2015-12-29 19:36
- Emax and ED50: NLME gcpatel126 2015-12-29 18:04
- Emax and ED50: NLMEHelmut 2015-12-29 17:46
- Emax and ED50: NLME gcpatel126 2015-12-29 15:49
- Emax and ED50: NLME SDavis 2015-12-15 11:50
- Emax and ED50: NLME gcpatel126 2015-12-10 17:34
- Emax and ED50: NLME Helmut 2015-12-10 02:09