Emax and ED50: NLME [Software]
Hi Simon,
Please find below FDA guideline data for calculation ED50 and Emax using nonlinear mixed effect model (population model). Please let me know value matches with guideline or not.
Thanks,
Dr. G C Patel
Edit: Reformatted with BBcodes. [Helmut]
Please find below FDA guideline data for calculation ED50 and Emax using nonlinear mixed effect model (population model). Please let me know value matches with guideline or not.
Subject Dose AUEC
(hrs)
1 0.25 -1.23
1 0.50 -7.39
1 0.75 -1.48
1 1.00 -3.80
1 1.50 -0.23
1 2.00 5.77
1 4.00 -4.74
1 6.00 -1.53
2 0.25 -0.02
2 0.50 -5.13
2 0.75 -8.92
2 1.00 -24.56
2 1.50 -19.21
2 2.00 -1.80
2 4.00 -43.07
2 6.00 -41.56
3 0.25 -13.87
3 0.50 -15.03
3 0.75 -18.39
3 1.00 -16.25
3 1.50 -15.44
3 2.00 -23.74
3 4.00 -24.80
3 6.00 -21.79
4 0.25 -27.27
4 0.50 -3.71
4 0.75 -43.82
4 1.00 -44.39
4 1.50 -77.04
4 2.00 -66.80
4 4.00 -62.96
4 6.00 -71.60
5 0.25 -10.65
5 0.50 7.72
5 0.75 -23.42
5 1.00 -20.37
5 1.50 -19.95
5 2.00 -32.00
5 4.00 -32.81
5 6.00 -61.51
6 0.25 -10.41
6 0.50 -5.94
6 0.75 -2.29
6 1.00 -8.92
6 1.50 -20.64
6 2.00 -19.52
6 4.00 -8.52
6 6.00 -19.01
7 0.25 4.20
7 0.50 -12.31
7 0.75 1.34
7 1.00 -18.84
7 1.50 -42.70
7 2.00 -37.29
7 4.00 -45.46
7 6.00 -37.24
8 0.25 -11.95
8 0.50 7.45
8 0.75 5.95
8 1.00 8.78
8 1.50 1.26
8 2.00 -48.83
8 4.00 -71.77
8 6.00 -8.14
9 0.25 -12.36
9 0.50 12.95
9 0.75 1.88
9 1.00 -43.35
9 1.50 -20.97
9 2.00 -39.79
9 4.00 -57.55
9 6.00 -34.18
10 0.25 1.15
10 0.50 -39.45
10 0.75 -40.68
10 1.00 -16.19
10 1.50 6.87
10 2.00 10.75
10 4.00 -37.64
10 6.00 -35.01
11 0.25 -30.03
11 0.50 -39.56
11 0.75 -61.06
11 1.00 -43.58
11 1.50 -40.73
11 2.00 -62.01
11 4.00 -27.82
11 6.00 -33.60
12 0.25 -7.25
12 0.50 14.73
12 0.75 -21.09
12 1.00 10.81
12 1.50 0.51
12 2.00 -10.51
12 4.00 -14.89
12 6.00 16.14
Thanks,
Dr. G C Patel
Edit: Reformatted with BBcodes. [Helmut]

Complete thread:
- Emax and ED50: NLME gcpatel126 2015-12-09 18:08 [Software]
- Emax and ED50: NLME Helmut 2015-12-10 02:09
- Emax and ED50: NLME gcpatel126 2015-12-10 17:34
- Emax and ED50: NLME SDavis 2015-12-15 11:50
- Emax and ED50: NLMEgcpatel126 2015-12-29 15:49
- Emax and ED50: NLME Helmut 2015-12-29 17:46
- Emax and ED50: NLME gcpatel126 2015-12-29 18:04
- Emax and ED50: NLME Helmut 2015-12-29 19:36
- Emax and ED50: NLME gcpatel126 2015-12-30 14:43
- Emax and ED50: NLME Helmut 2015-12-30 14:56
- Emax and ED50: NLME gcpatel126 2015-12-30 15:19
- Validation? Helmut 2015-12-30 16:02
- Validation? gcpatel126 2015-12-30 17:47
- Validation? Helmut 2015-12-30 21:15
- Validation? gcpatel126 2015-12-31 07:06
- Validation? gcpatel126 2016-01-11 14:54
- EOD Helmut 2016-01-11 22:13
- Validation? gcpatel126 2016-01-11 14:54
- Validation? gcpatel126 2015-12-31 07:06
- Validation? Helmut 2015-12-30 21:15
- Validation? gcpatel126 2015-12-30 17:47
- Validation? Helmut 2015-12-30 16:02
- Emax and ED50: NLME gcpatel126 2015-12-30 15:19
- Emax and ED50: NLME Helmut 2015-12-30 14:56
- Emax and ED50: NLME gcpatel126 2015-12-30 14:43
- Emax and ED50: NLME Helmut 2015-12-29 19:36
- Emax and ED50: NLME gcpatel126 2015-12-29 18:04
- Emax and ED50: NLME Helmut 2015-12-29 17:46
- Emax and ED50: NLMEgcpatel126 2015-12-29 15:49
- Emax and ED50: NLME SDavis 2015-12-15 11:50
- Emax and ED50: NLME gcpatel126 2015-12-10 17:34
- Emax and ED50: NLME Helmut 2015-12-10 02:09