Bioequivalence and Bioavailability Forum • bear v2.7.1

bear v2.7.1 [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2015-12-15 11:21 (3047 d 12:06 ago) – Posting: # 15729
Views: 26,782
(edited by yjlee168 on 2015-12-15 19:48)

Dear all,

I have released bear v2.7.1 to sourceforge. The major change was to fix the reported error. The error will occur if there is any zero conc. included when calculating λ_z (the terminal-phase elimination rate constant). It's because log(0) is equal to -Inf as shown in error message. If switching to manual selection of data points to avoid this error (not to select any zero conc.), it may complete the run without any error. However, it will result with AUC_0-t = AUC_0-inf and AUC_t-inf (extrapolated AUC) = 0 since C_last = 0. Actually, I don't know if we should call it as AUC_0-t or AUC_0-inf by definition. Although this has been mentioned in bear's website about data input, I decided to fix this error by throwing 'NA' to replace any conc. = 0 occurring at time ≠ 0. This error was also reported elsewhere (1 & 2) at this Forum by other users. Thanks for reading.

❝ ❝ Error in

❝ ❝ lm.fit(x, y, offset = offset, singular.ok = singular.ok, ...) :

❝ ❝ NA/NaN/Inf in 'y'

—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

bear v2.7.0 released yjlee168 2015-12-07 09:18 [🇷 for BE/BA]
- Suggestion ElMaestro 2015-12-07 10:12
  - Suggestion yjlee168 2015-12-07 10:55
    - Suggestion Helmut 2015-12-07 14:01
      - Suggestion yjlee168 2015-12-07 18:51
- bear v2.7.0 released Astea 2015-12-10 16:36
  - if Clast is zero in bear yjlee168 2015-12-10 17:23
    - if Clast is zero in bear Astea 2015-12-10 20:50
      - if Clast is zero in bear yjlee168 2015-12-11 03:28
        
        if Clast is zero in bear Astea 2015-12-11 09:39
        
        if Clast is zero in bear yjlee168 2015-12-11 17:16
    - bear v2.7.1yjlee168 2015-12-15 10:21
      - bear v2.7.1 Astea 2015-12-15 19:32
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
        
        BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
        
        BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
        
        BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
        
        BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
        
        zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
        
        BQL rules in bear mittyri 2016-02-01 22:16
        
        BQL rules in bear yjlee168 2016-02-02 10:59
        possible solutions? yjlee168 2016-02-02 21:30
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
        
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
        
        Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
        
        error message in bear mahmoud-teaima 2016-02-09 04:55
        
        please check your dataset file yjlee168 2016-02-09 06:40
        
        please check your dataset file mahmoud-teaima 2016-02-09 15:00
        
        please check your dataset file yjlee168 2016-02-09 15:38
        
        A possible R bug? yjlee168 2016-02-09 19:14