Bioequivalence and Bioavailability Forum • if Clast is zero in bear

if Clast is zero in bear [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2015-12-11 18:16 (3052 d 04:59 ago) – Posting: # 15724
Views: 27,218

Dear Astea,

❝ 1). I used linear-up/log-down method (1)

❝ 2). When 'NA' is marked for the last point BEAR gets λ_z in the following form (below I attach all the results for the verification):

OK. Thanks.

❝ ...

❝ And when we leave "0" and choose manual selection (three points):

❝ »<< NCA Outputs:- <Subj.# 1 > (Ref.)>>

❝ --------------------------------------------------------

❝ subj time conc AUC(0-t) AUMC(0-t)

❝ ...

❝ 1 3.00 1604.0 3309.275 6495.444

❝ 1 4.00 1460.0 4841.275 11821.444

❝ 1 8.00 797.0 9355.275 36253.444

❝ 1 12.00 383.0 11715.275 58197.444

❝ 1 24.00 0.0 14013.275 85773.444 <-

The zero-Clast should not be included even using manual selection method, though it will not cause any error in bear. This is because the extrapolated AUC (i.e. AUC_t-inf) will become zero (since Clast is zero). I don't think this is a correct approach. Looks like that I have to take care of this error with bear.

❝ ...

❝ It seems to me very strange that λ_z in BEAR are slightly different: 0.16708 and 0.16727. And the question is why the first method (that is calculating with manually selected 3 points) fails.

Oh? any error message? Thanks again.

—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

bear v2.7.0 released yjlee168 2015-12-07 09:18 [🇷 for BE/BA]
- Suggestion ElMaestro 2015-12-07 10:12
  - Suggestion yjlee168 2015-12-07 10:55
    - Suggestion Helmut 2015-12-07 14:01
      - Suggestion yjlee168 2015-12-07 18:51
- bear v2.7.0 released Astea 2015-12-10 16:36
  - if Clast is zero in bear yjlee168 2015-12-10 17:23
    - if Clast is zero in bear Astea 2015-12-10 20:50
      - if Clast is zero in bear yjlee168 2015-12-11 03:28
        
        if Clast is zero in bear Astea 2015-12-11 09:39
        
        if Clast is zero in bearyjlee168 2015-12-11 17:16
    - bear v2.7.1 yjlee168 2015-12-15 10:21
      - bear v2.7.1 Astea 2015-12-15 19:32
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
        
        BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
        
        BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
        
        BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
        
        BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
        
        zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
        
        BQL rules in bear mittyri 2016-02-01 22:16
        
        BQL rules in bear yjlee168 2016-02-02 10:59
        possible solutions? yjlee168 2016-02-02 21:30
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
        
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
        
        Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
        
        error message in bear mahmoud-teaima 2016-02-09 04:55
        
        please check your dataset file yjlee168 2016-02-09 06:40
        
        please check your dataset file mahmoud-teaima 2016-02-09 15:00
        
        please check your dataset file yjlee168 2016-02-09 15:38
        
        A possible R bug? yjlee168 2016-02-09 19:14