if Clast is zero in bear [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2015-12-11 04:28 (3355 d 05:52 ago) – Posting: # 15721
Views: 28,711

Dear Astea,

❝ The problem is in understanding definitions, there are so many AUC (see this thread)...


Thank you for your pointer. So bear uses Method #4 to calculate AUC0-inf.

❝ ... I think, BEAR calculates AUC0-inf=AUClast+Cobs/lambdaz, isn't it?


Yes, that's correct.

❝ I've made several calculations and came to the conclusion...


In order to verify your results as posted, could you please tell me (1) what AUC calculation method you used with bear ('all linear' or 'linear-up/log-down')? (2) what λz values you got with bear (when input 'NA' for the last data point) and with excel? and (3) what λz calculation did you use with non-manual selection of data points? Thanks again.

All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

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