if Clast is zero in bear [🇷 for BE/BA]
Dear Astea,
Thank you for your pointer. So bear uses
Yes, that's correct.
In order to verify your results as posted, could you please tell me (1) what AUC calculation method you used with bear ('all linear' or 'linear-up/log-down')? (2) what λz values you got with bear (when input 'NA' for the last data point) and with excel? and (3) what λz calculation did you use with non-manual selection of data points? Thanks again.
❝ The problem is in understanding definitions, there are so many AUC (see this thread)...
Thank you for your pointer. So bear uses
Method #4
to calculate AUC0-inf.❝ ... I think, BEAR calculates AUC0-inf=AUClast+Cobs/lambdaz, isn't it?
Yes, that's correct.
❝ I've made several calculations and came to the conclusion...
In order to verify your results as posted, could you please tell me (1) what AUC calculation method you used with bear ('all linear' or 'linear-up/log-down')? (2) what λz values you got with bear (when input 'NA' for the last data point) and with excel? and (3) what λz calculation did you use with non-manual selection of data points? Thanks again.
—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
Complete thread:
- bear v2.7.0 released yjlee168 2015-12-07 09:18 [🇷 for BE/BA]
- Suggestion ElMaestro 2015-12-07 10:12
- Suggestion yjlee168 2015-12-07 10:55
- Suggestion Helmut 2015-12-07 14:01
- Suggestion yjlee168 2015-12-07 18:51
- Suggestion Helmut 2015-12-07 14:01
- Suggestion yjlee168 2015-12-07 10:55
- bear v2.7.0 released Astea 2015-12-10 16:36
- if Clast is zero in bear yjlee168 2015-12-10 17:23
- if Clast is zero in bear Astea 2015-12-10 20:50
- if Clast is zero in bearyjlee168 2015-12-11 03:28
- if Clast is zero in bear Astea 2015-12-11 09:39
- if Clast is zero in bear yjlee168 2015-12-11 17:16
- if Clast is zero in bear Astea 2015-12-11 09:39
- if Clast is zero in bearyjlee168 2015-12-11 03:28
- bear v2.7.1 yjlee168 2015-12-15 10:21
- bear v2.7.1 Astea 2015-12-15 19:32
- BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
- BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
- BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
- BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
- BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
- BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
- zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
- BQL rules in bear mittyri 2016-02-01 22:16
- BQL rules in bear yjlee168 2016-02-02 10:59
- possible solutions? yjlee168 2016-02-02 21:30
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
- Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
- error message in bear mahmoud-teaima 2016-02-09 04:55
- please check your dataset file yjlee168 2016-02-09 06:40
- please check your dataset file mahmoud-teaima 2016-02-09 15:00
- please check your dataset file yjlee168 2016-02-09 15:38
- please check your dataset file mahmoud-teaima 2016-02-09 15:00
- A possible R bug? yjlee168 2016-02-09 19:14
- Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
- BQL rules in bear mittyri 2016-02-01 22:16
- zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
- BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
- BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
- BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
- BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
- BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
- BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
- bear v2.7.1 Astea 2015-12-15 19:32
- if Clast is zero in bear Astea 2015-12-10 20:50
- if Clast is zero in bear yjlee168 2015-12-10 17:23
- Suggestion ElMaestro 2015-12-07 10:12