bear v2.7.0 released [🇷 for BE/BA]

posted by Astea – Russia, 2015-12-10 17:36 (3031 d 20:06 ago) – Posting: # 15717
Views: 27,254

Dear yjlee168!

Firstly, thank you a lot for your unique program!

I've got some questions about calculations. Do I understand correctly that BEAR can calculate only AUCall but not AUClast?
What is the formula for AUCinf calculation? I guess it is like AUCinf=AUCall+C/lambda_z, where C is the observed concentration in the last point, so AUCinf is actually AUCinf_obs, based on AUCall, am I right?

Why does BEAR crash when there is a zero-concentration in the last point? (I change only one point: last point in concentrations of the first subject in the Single2x2x2 demo-data and BEAR returns:

Error in
lm.fit(x, y, offset = offset, singular.ok = singular.ok, ...) :
NA/NaN/Inf in 'y'

It allows calculation only for the manual selection of points. Thats very uncomfortably especially when we want to get primary information on the confidence intervals for AUC and Cmax. There is no need to calculate lambda_z and AUCinf if we just want to calculate AUC and Cmax...

"Being in minority, even a minority of one, did not make you mad"

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
112 visitors (0 registered, 112 guests [including 9 identified bots]).
Forum time: 13:43 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5