Bioequivalence and Bioavailability Forum • bear v2.7.0 released

bear v2.7.0 released [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2015-12-07 10:18 (3062 d 10:01 ago) – Posting: # 15699
Views: 29,725
(edited by yjlee168 on 2015-12-07 11:14)

Dear all,

I have released bear v2.7.0 to sourceforge. One minor change in this release is to check all dataset first to make sure that all subjects' λ_z (terminal-phase elimination rate constant, or 'ke' or 'kel') can be calculated before going to NCA, based on selected λ_z calculation method (ARS, AIC, TTT, TTTARS or TTTAIC). This error has been reported by some users (such as here and here). The error messages are something like Error in NAToUnknown.default(x = ke, unknown = 0) : 'x' already has value “0”

Basically, ARS or AIC uses the same criteria to check the dataset (OK if > 2 data points after Tmax). TTT and its combination forms use the criteria of "OK if > 2 data points after 2*Tmax". The not-OK subject's data will be listed on R console/terminal. If there is any subject found not meet the criteria of selected λ_z, bear will be aborted and go back to the top menu. If this is the case, users need to decide to (i) change the λ_z calculation method (manual selection?); or (ii) consider to delete the entire subject from dataset if necessary.

That's it and thank you for reading.

Ps. The dataset checking function was built inside the original codes (not on the menu list); so if the dataset is OK, bear continues as usual. [added after OP]

—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

bear v2.7.0 releasedyjlee168 2015-12-07 09:18 [🇷 for BE/BA]
- Suggestion ElMaestro 2015-12-07 10:12
  - Suggestion yjlee168 2015-12-07 10:55
    - Suggestion Helmut 2015-12-07 14:01
      - Suggestion yjlee168 2015-12-07 18:51
- bear v2.7.0 released Astea 2015-12-10 16:36
  - if Clast is zero in bear yjlee168 2015-12-10 17:23
    - if Clast is zero in bear Astea 2015-12-10 20:50
      - if Clast is zero in bear yjlee168 2015-12-11 03:28
        
        if Clast is zero in bear Astea 2015-12-11 09:39
        
        if Clast is zero in bear yjlee168 2015-12-11 17:16
    - bear v2.7.1 yjlee168 2015-12-15 10:21
      - bear v2.7.1 Astea 2015-12-15 19:32
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
        
        BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
        
        BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
        
        BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
        
        BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
        
        zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
        
        BQL rules in bear mittyri 2016-02-01 22:16
        
        BQL rules in bear yjlee168 2016-02-02 10:59
        possible solutions? yjlee168 2016-02-02 21:30
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
        
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
        
        Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
        
        error message in bear mahmoud-teaima 2016-02-09 04:55
        
        please check your dataset file yjlee168 2016-02-09 06:40
        
        please check your dataset file mahmoud-teaima 2016-02-09 15:00
        
        please check your dataset file yjlee168 2016-02-09 15:38
        
        A possible R bug? yjlee168 2016-02-09 19:14