Bioequivalence and Bioavailability Forum

An other one with 0.0304 [Two-Stage / GS Designs]

posted by Helmut  – Vienna, Austria, 2015-12-03 17:26 (3058 d 18:05 ago) – Posting: # 15697
Views: 11,989

Dear Detlew,

❝ I have another one:

❝ Gould A. L.

❝ "Group Sequential Extensions of a Standard Bioequivalence Testing Procedure"

❝ Journal of Pharmacokinetics and Biopharmaceutics. Vol 23. No.1. 1995

❝ Table I: critical value for n1=n2: 1.8753

How could I forget Mr Gould? He was first in exploring this stuff for BE-studies.

rep(1-pnorm(1.8753), 2)
[1] 0.03037573 0.03037573

BTW, in the late 1990s I tried his method (scientific advices in France and Germany). Both didn’t accept it.

❝ That means on the other hand: Potvin und Konsorten were much more lucky then they should have been.

Yep. Lucky punch.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Science Quotes

Complete thread:

• Adaptive TSD vs. “classical” GSD Helmut 2015-11-27 19:05 
  • Adaptive TSD vs. “classical” GSD ElMaestro 2015-11-27 19:54
  • “classical” GSD - E[n] d_labes 2015-11-30 11:15
    • Apples are pears by comparing the weight Helmut 2015-12-01 16:35
      • Apples are pears by comparing the weight d_labes 2015-12-03 09:16
        • Apples are pears by comparing the weight Helmut 2015-12-03 13:10
          • Oranges d_labes 2015-12-03 13:56
  • Adaptive TSD vs. “classical” GSD Ben 2015-12-02 19:27
    • Adaptive TSD vs. “classical” GSD Helmut 2015-12-03 03:11
      • “classical” GSD alpha's d_labes 2015-12-03 09:47
        • N sufficiently large‽ Helmut 2015-12-03 14:56
          • An other one with 0.0304 d_labes 2015-12-03 16:15
            • An other one with 0.0304Helmut 2015-12-03 16:26
      • Adaptive TSD vs. “classical” GSD Ben 2016-01-10 12:43