AUMC ⇒ MRT [PK / PD]
BE-proff,
In the BE-context you generally don’t need it at all. It’s only an intermediate step in calculating MRT. Who asked for it?
We can see plasma profiles as the result of a stochastic process (drug molecules are absorbed, distributed, and metabolized/excreted). At any given time point a certain fraction is in the circulation. Hey, that’s a statistical distribution!
Distributions can be described by ‘statistical moments’
S2 is rarely used (for the calculation of the ‘Variance of Residence Times’): VRT = S2/S0 – (S1/S0)2. MRT and VRT are the coordinates (x|y) of the ‘center of gravity’ of the profile. Try it: Plot a PK-curve on cardboard and stick a pin through x|y. Makes a nice children’s wind wheel.
❝ […] I can't catch the idea why AUMC is required?
In the BE-context you generally don’t need it at all. It’s only an intermediate step in calculating MRT. Who asked for it?
❝ Can anybody explain me?
We can see plasma profiles as the result of a stochastic process (drug molecules are absorbed, distributed, and metabolized/excreted). At any given time point a certain fraction is in the circulation. Hey, that’s a statistical distribution!
Distributions can be described by ‘statistical moments’
\(S_0=\int f(x)dx\)
\(S_1=\int x\cdot f(x)dx\)
\(S_2=\int x^2\cdot f(x)dx\)
- iv bolus
MRT = AUMC / AUC
- and for infusion (of length tinf)
MRT = AUMC / AUC – ½tinf
S2 is rarely used (for the calculation of the ‘Variance of Residence Times’): VRT = S2/S0 – (S1/S0)2. MRT and VRT are the coordinates (x|y) of the ‘center of gravity’ of the profile. Try it: Plot a PK-curve on cardboard and stick a pin through x|y. Makes a nice children’s wind wheel.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Why do we need AUMC? BE-proff 2015-11-02 14:24 [PK / PD]
- Why do we need AUMC? mittyri 2015-11-02 14:44
- Do we need MRT? d_labes 2015-11-02 14:55
- AUMC ⇒ MRTHelmut 2015-11-02 15:13
- AUMC ⇒ MRT BE-proff 2015-11-02 19:18
- AUMC ⇒ MRT yjlee168 2015-11-02 19:43
- AUMC ⇒ MRT BE-proff 2015-11-02 19:18
- Why do we need AUMC? mittyri 2015-11-02 14:44