Ct curves from single dose to pre­dict multiple dose [Software]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2015-10-09 08:39 (3411 d 18:32 ago) – Posting: # 15535
Views: 13,930

Dear Detlew,

I assume that you want do following:
  1. to obtain PK parameters first from your single-dose Ct;
    [image]
  2. to use known PK parameters to simulate multiple-dose in general simulations or Monte-Carlo simulations.
    [image]
    (with <= +/-10% uniform errors added to calc. Ct)

    [image]
    (20's MC simulations)

As Helmut said that there are some commercial or freeware software should do the same jobs. Freeware includes Boomer or ADAPT (required FORTRAN compiler).

❝ Does anybody knows any software to accomplish this task or has some code in f.i. R for superposition the concentration time curves after single dose application?


Introducing PKfit if you prefer using R. The plots are created with PKfit. I am very happy to help if you are really interested in using PKfit. Hope this can help.

All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

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