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RegisterPhoenix/WinNonlin: NonParametric Superposition [Software]
posted by Helmut 
– Vienna, Austria, 2015-10-08 23:02 (3544 d 10:36 ago) – Posting: # 15534
Views: 14,664
Dear Detlew,
in Phoenix/WinNonlin there is a dedicated tool called “NonParametric Superpostion” which does exactly what you need.
PK-Xpress has such a function as well. In a WebEx-presentation last summer it turned out that only the linear trapezoidal was implemented. Not a good idea to stack in each dosing interval another positive bias on top of the ones before.
in Phoenix/WinNonlin there is a dedicated tool called “NonParametric Superpostion” which does exactly what you need.
- Performs NCA (Pharsight recommends the log trapezoidal); needs a reliable estimate of λz.
- ⇒ Define doses and dosing intervals.
- ⇒ Click the button.
Stacks according to Mr Dost’s “Gesetz der korrespondieren Flächen” (1953).
- Easy, if you have both equal doses and dosing intervals.
- Moderate, for unequal doses but equal τs.
- Nasty, if both can vary. Never seen that in the world of BE anyway.
PK-Xpress has such a function as well. In a WebEx-presentation last summer it turned out that only the linear trapezoidal was implemented. Not a good idea to stack in each dosing interval another positive bias on top of the ones before.
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Ct curves from single dose to predict multiple dose d_labes 2015-10-08 19:57 [Software]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Phoenix/WinNonlin: NonParametric SuperpositionHelmut 2015-10-08 21:02
- Ct curves from single dose to predict multiple dose yjlee168 2015-10-09 06:39
- Software for superposition d_labes 2015-10-09 08:46
- PK-Xpress: impressions Helmut 2015-10-09 14:23
- PK-Xpress: impressions d_labes 2015-10-09 20:23
- OT: list limbo and (X)HTML Helmut 2015-10-10 01:06
- OT: list limbo and (X)HTML Ohlbe 2015-10-10 23:15
- OT: list limbo and (X)HTML Helmut 2015-10-11 00:01
- OT: list limbo and (X)HTML d_labes 2015-10-11 14:55
- OT: list limbo and (X)HTML Ohlbe 2015-10-10 23:15
- OT: list limbo and (X)HTML Helmut 2015-10-10 01:06
- PK-Xpress: impressions d_labes 2015-10-09 20:23
- PK-Xpress: impressions Helmut 2015-10-09 14:23
- JGuiB Helmut 2015-10-09 13:16
- Software for superposition d_labes 2015-10-09 08:46
Ing. Helmut Schütz