Bioequivalence and Bioavailability Forum • Power to the people

Power to the people [Two-Stage / GS Designs]

posted by john john – Spain, 2015-10-07 16:54 (3447 d 16:29 ago) – Posting: # 15526
Views: 11,158

Hi Detlew

❝ Here my results:

❝ # Cmax

❝ power.TOST(alpha=0.0294, CV=0.387, n=36, theta0=0.95)

❝ [1] 0.3783821

❝ # AUC

❝ power.TOST(alpha=0.0294, CV=0.324, n=36, theta0=0.95)

❝ [1] 0.5946074

❝

❝ Both are below the targeted 80%. Thus your problem described above doesn't exists.

We have worked with CI of 94.12 and alpha 0.0294

Regards

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

Complete thread:

Sequential trial with B method of Potvin john john 2015-10-01 17:44 [Two-Stage / GS Designs]
- Sequential trial with B method of Potvin ElMaestro 2015-10-01 17:58
- Sequential trial with B method of Potvin Helmut 2015-10-01 18:13
  - Sequential trial with B method of Potvin john john 2015-10-07 11:26
    - Power to the people d_labes 2015-10-07 13:49
      - Power to the peoplejohn john 2015-10-07 14:54
        
        Software? Ethics beyond statistics… Helmut 2015-10-07 16:06
        
        Subtraction of a df ElMaestro 2015-10-07 21:22
        
        df = df-1 d_labes 2015-10-08 08:10
    - Potvin B: α 0.0294 in both stages Helmut 2015-10-08 15:27
      - Potvin B: α 0.0294 in both stages john john 2015-10-23 12:04