Sequential trial with B method of Potvin [Two-Stage / GS Designs]

posted by john john – Spain, 2015-10-07 13:26 (3095 d 08:45 ago) – Posting: # 15524
Views: 9,968

Hi

Sorry for the delay. I give you our numbers: n1 was 36 subjects balanced 18RT and 18TR

Cmax   CVintrasub (0.387)  Ratio(%Ref) (81.439)
               BEQ (70.162-94.529)
              Power at 20% (0.715)

AUC0-t CVintrasub (0.324)  Ratio(%Ref) (110.662)
              BEQ (97.552-125.534)
             Power at 20% (0.846)

AUC0-30       BEQ (84.314-105.609)


Thanks for your help

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
70 visitors (0 registered, 70 guests [including 9 identified bots]).
Forum time: 21:12 CET (Europe/Vienna)

Nothing shows a lack of mathematical education more
than an overly precise calculation.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5