Bioequivalence and Bioavailability Forum • Sequential trial with B method of Potvin

Sequential trial with B method of Potvin [Two-Stage / GS Designs]

posted by john john – Spain, 2015-10-07 13:26 (3447 d 17:59 ago) – Posting: # 15524
Views: 11,090

Hi

Sorry for the delay. I give you our numbers: n₁ was 36 subjects balanced 18_RT and 18_TR

Cmax   CVintrasub (0.387)  Ratio(%Ref) (81.439) 

               BEQ (70.162-94.529)

              Power at 20% (0.715)



AUC0-t CVintrasub (0.324)  Ratio(%Ref) (110.662) 

              BEQ (97.552-125.534)

             Power at 20% (0.846)



AUC0-30       BEQ (84.314-105.609)

Thanks for your help

Complete thread:

Sequential trial with B method of Potvin john john 2015-10-01 17:44 [Two-Stage / GS Designs]
- Sequential trial with B method of Potvin ElMaestro 2015-10-01 17:58
- Sequential trial with B method of Potvin Helmut 2015-10-01 18:13
  - Sequential trial with B method of Potvinjohn john 2015-10-07 11:26
    - Power to the people d_labes 2015-10-07 13:49
      - Power to the people john john 2015-10-07 14:54
        
        Software? Ethics beyond statistics… Helmut 2015-10-07 16:06
        
        Subtraction of a df ElMaestro 2015-10-07 21:22
        
        df = df-1 d_labes 2015-10-08 08:10
    - Potvin B: α 0.0294 in both stages Helmut 2015-10-08 15:27
      - Potvin B: α 0.0294 in both stages john john 2015-10-23 12:04