Baseline correction examples [Regulatives / Guidelines]

posted by Lucas – Brazil, 2015-09-18 16:19 (3433 d 07:34 ago) – Posting: # 15430
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Thanks for the graphic representation Helmut!

That does help a lot, and I agree with the method. Two questions though:
1. Do you know a example of a endogenous substance that has a constant (or nearly constant enough) baseline level in the first example of yours?
2. I see that you only considered one baseline profile. We wouldn't have to measure the baseline level before each period of the study because we ate assuming that the cycle is the same through time. Right? But what about feminine hormones produced in a 28-day cycle?

I've also seen a lot of what you've described in the last graph, our triangulation points (or embedded concentrations) that we've discussed. :-D

Regards

Lucas

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