Bioequivalence and Bioavailability Forum

Spaghetti viennese [🇷 for BE/BA]

posted by d_labes  – Berlin, Germany, 2015-08-17 10:45 (3500 d 06:38 ago) – Posting: # 15276
Views: 11,668

Dear Helmut, dear Mittyri,

❝ ❝ Detlew, what about implementation in PowerTOST both branches?

❝

❝ I would say that’s overkill. In PowerTOST almost everything is vec­tor­ized (i.e., you can assess different CVs for T and R, calculate power for unbalanced sequences, etc.). I wouldn’t do that.

First: Good job .

Second: IMHO much too much coding. Why not doing simply 2 sampleN.xyz() calls and decide with own brain which metric drives the sample size? And voila - you have the first 5 results lines of the examples above.
A third function call of power.xyz() will give you the information in the sixth line of your examples (power of the metric not driving the sample size at choosen sample size).
If the last information, lowest GMR, is really needed is a matter of taste. IMHO it's only "nice to know". Educating regulators with that information would postulate that they read the sample size estimation chapter of the study protocol. I strongly doubt ...

Thus, third: Full ACK with Helmut: It's overkill.

BTW: Lowest GMR which assures target power reminds me to Dave's BOSS button in FARTSSIE .

Complete thread:

• Power calculation BE-proff 2015-08-13 13:44 [🇷 for BE/BA] 
  • Power calculation Helmut 2015-08-13 13:59
    • Power calculation BE-proff 2015-08-13 14:44
      • Example(s) Helmut 2015-08-13 14:58
        • Power parallel group: PowerTOST/SAS/PASS d_labes 2015-08-14 10:29
          • Power parallel group: PowerTOST/SAS/PASS Helmut 2015-08-14 15:34
      • Slippery ground d_labes 2015-08-14 10:50
        • Advanced example Helmut 2015-08-14 16:41
          • Advanced example for 2X2X2 mittyri 2015-08-14 19:40
            • Spaghetti viennese Helmut 2015-08-15 03:22
              • Spaghetti viennesed_labes 2015-08-17 08:45
          • Advanced example BE-proff 2015-08-17 08:55