R-SABE and ABEL versus Blood Volume [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2015-08-11 19:31 (3477 d 01:26 ago) – Posting: # 15234
Views: 5,185

Hi Lucas,

❝ Hi Helmut! Do you believe that I still can't access the forum via my work computer?


If you tell…

❝ That's a unsolved mystery! :-D


It’s easier to be blacklisted than to get out of the trap. Can you e-mail your office PC’s IP again?

❝ PASS gives, for example, a result of 260 subjects to achieve 80% power with a ISCV of 40% and a true ratio of 95%, if I'm not mistaken... It's not very practical.


Confirmed:

library(PowerTOST)
sampleN.TOST(CV=0.4, design="2x4x2")
+++++++++++ Equivalence test - TOST +++++++++++
            Sample size estimation
-----------------------------------------------
Study design:  Balaam's (2x4x2)
log-transformed data (multiplicative model)

alpha = 0.05, target power = 0.8
BE margins        = 0.8 ... 1.25
Null (true) ratio = 0.95,  CV = 0.4

Sample size (total)
 n     power
260   0.805585

But: I would not assume a ratio of 0.95 for a HVD/HVDP. For 0.90 the sample size explodes to 532.

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