R-SABE and ABEL versus Blood Volume [Design Issues]
Hi Lucas,
yep, combos can be challenging when it comes to the blood volume. What I have seen is to optimize the sampling schedule for each drug and split samples accordingly. Drawbacks:
Not sure whether I understand you. Can you post sequences / periods you have in mind?
Correct. In Balaam’s design we throw away half of the sample size in the estimation of T/R. Furthermore, I don’t know how to estimate the sample size. RT|TR|RR|TT is currently not implemented in
yep, combos can be challenging when it comes to the blood volume. What I have seen is to optimize the sampling schedule for each drug and split samples accordingly. Drawbacks:
- Makes only sense if the PK is substantially different.
- The logistics is challenging. We color-coded all vials and even the respective rows in the CRF. Turned out to be not fail-safe.
- I have never seen something like this for more than two drugs.
❝ is it possible to not use the replicated samples for the other 2 drugs and apply conventional ABE for them, and consider the replication only for the HVD?
Not sure whether I understand you. Can you post sequences / periods you have in mind?
❝ Other option would be to use Balaam's 4x2 design, but I don't think that someone has budget for that...
Correct. In Balaam’s design we throw away half of the sample size in the estimation of T/R. Furthermore, I don’t know how to estimate the sample size. RT|TR|RR|TT is currently not implemented in
PowerTOST sampleN.scABEL()
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
- R-SABE and ABEL versus Blood Volume Lucas 2015-08-11 16:06 [Design Issues]
- R-SABE and ABEL versus Blood VolumeHelmut 2015-08-11 16:41
- R-SABE and ABEL versus Blood Volume Lucas 2015-08-11 17:04
- R-SABE and ABEL versus Blood Volume Helmut 2015-08-11 17:31
- R-SABE and ABEL versus Blood Volume Lucas 2015-08-11 18:26
- R-SABE and ABEL versus Blood Volume Helmut 2015-08-11 17:31
- R-SABE and ABEL versus Blood Volume Lucas 2015-08-11 17:04
- R-SABE and ABEL versus Blood VolumeHelmut 2015-08-11 16:41