Bioequivalence and Bioavailability Forum • Sample size justification

Sample size justification [Design Issues]

posted by BE-proff – 2015-08-06 16:19 (3514 d 10:07 ago) – Posting: # 15187
Views: 11,906

Hi,bkrao

PASS simulator says 18 subjects will be enough with power 90%

mean ratio can be given from your pilot study with 12% COV.

I think you can always refer to that pilot study to justify parameters selection for size calculation

Complete thread:

Sample size justification bkrao 2015-08-06 09:12 [Design Issues]
- Sample size justificationBE-proff 2015-08-06 14:19
  - PASS simulator? d_labes 2015-08-06 15:25
    - PASS simulator? BE-proff 2015-08-07 20:08
      - Owen’s Q | noncentral t | shifted central t Helmut 2015-08-08 02:32
        
        Owen’s Q | noncentral t | shifted central t BE-proff 2015-08-09 15:36
        
        PowerTOST crash-course Helmut 2015-08-09 16:40
        
        Owen’s Q | noncentral t | shifted central t - PASS? d_labes 2015-08-10 11:30
- Sample size justification Helmut 2015-08-07 01:21
  - Sample size justification bkrao 2015-08-07 06:06
    - Guesstimates Helmut 2015-08-07 13:53
      - Guesstimates bkrao 2015-08-08 06:03
        
        Guesstimates jag009 2015-08-10 20:08
        
        Guesstimates bkrao 2015-08-10 20:44