Almighty oracle's mysterious saying [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2015-07-24 10:23 (3189 d 17:56 ago) – Posting: # 15140
Views: 27,202

Dear Helmut!

Parturient montes, nascetur ridiculus mus. Horace (Ars poetica, Ep.II.3, 139)


Full ACK :-D

As every Pythia's saying: Mysterious!
Nowhere in the scABEL method there is an term utilizing the 'uncertainty' of the variability of the reference.
Contrary to the FDA RSABE which has such a term.
That's the reason why both 3-period designs (TRR|RTR|RRT or TRT|RTR) require similar numbers of subjects.

And deeming 12 subjects as sufficient to 'control' that 'uncertainty' is at least strange (politely spoken):
library(PowerTOST)
CVCL(CV=0.3, df=12-2, "2-sided")
 lower CL  upper CL
0.2072921 0.5513299

From no widening up to cap on widening!

But the net effect is of course pleasing :cool:.

Regards,

Detlew

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