Bonferroni (three tests) [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2015-07-09 14:18 (3510 d 02:32 ago) – Posting: # 15059
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Hi PJS,

❝ I am not statistician, so i might be wrong. But as far as i understand if three test products are compared against the one reference product in a single study, then the study title shold be 4 treatment, four sequence (?).


I’m neither Sherlock Holmes nor do I own a crystal ball. I have no clue what was done in this study.

❝ It has been two treatemnt, two sequence in the title.

❝ Or they have removed the other test product results from the study and used the Bonferroni correction?


No idea. Concluding from the title to what was actually done might be misleading. I know one nitpicking Polish assessor regularly rejecting protocols for the title “A bioequivalence study…”. His argument is: The title should be “A comparative bioavailability study…”. Bioequivalence is the desired result.

I still hold that Bonferroni’s correction was applied because none of the other multiplicity corrections or adaptive methods (with interim analysis/es) would lead to such an α.

❝ One article that helped understand some aspects is article


THX for mentioning my friend Jiří Hofmann’s presentation! In the future please don’t use a 300+ charac­ter link pointing to [image]-India but the URL of the document itself.

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