Bioequivalence and Bioavailability Forum • Degrees of freedom 3-period full replicate

Degrees of freedom 3-period full replicate [RSABE / ABEL]

posted by ElMaestro – Denmark, 2015-07-06 13:59 (3211 d 00:16 ago) – Posting: # 15043
Views: 27,709

Hi d_labes,

❝ Your SAS code according to the EMA crippled model with Proc GLM gives:

❝ degrees of freedom

❝ source type I type III

❝ subject 73 72


❝   -sequence             1        0

❝   -subject(sequence)   72       72
❝ period                  1        1
❝ error                  34       34

❝ total 108 108

❝ The type III df=0 for sequence or the changing df for subjects effects illustrates the typical mess with the EMA model.

I would like to offer an alternative view here:
DF=0 for sequence may be correct cf. the ordinary interpretation of type III SS and the use of the bogus statement.

What I absolutely do not get is that 72+1+34 is supposed to give 108? Or what am I overlooking, perhaps this is just the power to confuse.

—
Pass or fail!
ElMaestro

Complete thread:

3 period full replicate Dr_Dan 2015-06-24 13:55 [RSABE / ABEL]
- 3 period full replicate ElMaestro 2015-06-24 14:11
- 3 period full replicate Helmut 2015-06-24 14:29
- 3 period full replicate d_labes 2015-06-24 14:38
  - 3 period full replicate Dr_Dan 2015-06-24 16:43
    - 3 period full replicate Helmut 2015-06-24 18:00
      - 3 period full replicate ElMaestro 2015-06-24 18:11
        
        3 period full replicate Helmut 2015-06-24 18:25
        
        3 period full replicate d_labes 2015-06-25 08:52
        
        3 period full replicate ElMaestro 2015-06-25 10:37
        
        OT d_labes 2015-06-25 11:20
        
        OT ElMaestro 2015-06-25 11:54
        
        OT d_labes 2015-06-25 13:51
    - CVs (borderline OT) Helmut 2015-06-26 13:51
      - CVs (R, T) from pooled CV d_labes 2015-07-02 09:09
        
        Answering an unasked question Helmut 2015-07-02 13:03
        
        Answer to an unasked answer d_labes 2015-07-02 14:21
        
        Bloody typo! Helmut 2015-07-02 14:33
      - CVs (borderline OT) zizou 2015-07-05 19:20
        
        Degrees of freedom 3-period full replicate d_labes 2015-07-06 11:10
        
        Degrees of freedom 3-period full replicateElMaestro 2015-07-06 11:59
        
        Degrees of freedom 3-period full replicate d_labes 2015-07-06 13:53
        
        Degrees of freedom 3-period full replicate zizou 2015-07-06 17:25
- The almighty oracle has spoken! Helmut 2015-07-23 23:54
  - Almighty oracle's mysterious saying d_labes 2015-07-24 08:23