Playing around with α (not exactly brilliant) [Regulatives / Guidelines]
Hi Helmut,
I see your points, however, but how did they relate to my point? I reckon we address two different aspects. It is likely a question of bad explanations on my part.
Consider this:
My point was/is that changing the acceptance range for the CI in mathematical terms does exactly the same as keeping the acceptance range while changing the applied alpha.
I see your points, however, but how did they relate to my point? I reckon we address two different aspects. It is likely a question of bad explanations on my part.
Consider this:
- For any CV measured you can define a revised acceptance range while keeping the originally applied alpha (5%).
- For any CV measured I can define a revised alpha that keeps the original acceptance range in place (80.00%-125.00%), and which achieves exactly the same (it rejects and accepts exactly the same products as your approach).
My point was/is that changing the acceptance range for the CI in mathematical terms does exactly the same as keeping the acceptance range while changing the applied alpha.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- HC Proposed Policy on Bioequivalence Standards for HVDS balakotu 2015-07-02 09:05 [Regulatives / Guidelines]
- HC Proposed Policy on Bioequivalence Standards for HVDS d_labes 2015-07-02 09:19
- Bloody partial replicate again Helmut 2015-07-02 13:20
- Bloody partial replicate again Lucas 2015-07-02 13:35
- Which model? Helmut 2015-07-02 16:41
- Which model? Lucas 2015-07-02 18:06
- Which model? Helmut 2015-07-02 16:41
- Bloody partial replicate again Lucas 2015-07-02 13:35
- HC Proposed Policy on Bioequivalence Standards for HVDS drgunasakaran1 2015-07-02 17:08
- AUC and Cmax Helmut 2015-07-02 17:37
- HC for HVDs d_labes 2015-07-03 08:21
- HC for HVDs Helmut 2015-07-03 11:55
- Rounding d_labes 2015-07-03 12:53
- Acceptable difference (BE history) Helmut 2015-07-03 14:49
- Off topic ElMaestro 2015-07-03 13:02
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 15:38
- Playing around with α (not exactly brilliant)ElMaestro 2015-07-03 16:35
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 16:44
- OT – Philosophers on duty d_labes 2015-07-03 21:11
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 16:44
- Playing around with α (not exactly brilliant)ElMaestro 2015-07-03 16:35
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 15:38
- Rounding d_labes 2015-07-03 12:53
- HC for HVDs Helmut 2015-07-03 11:55