Off topic [Regulatives / Guidelines]
Hi all,
I am still baffled by scaling, whichever way it is done. Granted, I do not understand much of BE and in particular I am struggling with scaling. I am baffled for this reason:
As an alternative to scaling we might in stead relax the alpha and keep accepting and rejecting the same products. We would achieve not just roughly the same but exactly the same because scaling keeps the GMR unaffected. A practical matter is of course to identify the mathematical relationship between the scaling constant of acceptance range and scaling of alpha but this is nothing more than a practicality (find a closed form or chose empery, whatever works for you).
I think the only reason not to formulate the problem (=acceptance vs rejection) in terms of alpha relaxation but rather in terms of widening of CI limits is that if we formulate it as a widening of alpha level then we need to admit explicitly what scaling involves: An occasional increase in type I error.
Prove me wrong, please.
I am still baffled by scaling, whichever way it is done. Granted, I do not understand much of BE and in particular I am struggling with scaling. I am baffled for this reason:
As an alternative to scaling we might in stead relax the alpha and keep accepting and rejecting the same products. We would achieve not just roughly the same but exactly the same because scaling keeps the GMR unaffected. A practical matter is of course to identify the mathematical relationship between the scaling constant of acceptance range and scaling of alpha but this is nothing more than a practicality (find a closed form or chose empery, whatever works for you).
I think the only reason not to formulate the problem (=acceptance vs rejection) in terms of alpha relaxation but rather in terms of widening of CI limits is that if we formulate it as a widening of alpha level then we need to admit explicitly what scaling involves: An occasional increase in type I error.
Prove me wrong, please.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- HC Proposed Policy on Bioequivalence Standards for HVDS balakotu 2015-07-02 09:05 [Regulatives / Guidelines]
- HC Proposed Policy on Bioequivalence Standards for HVDS d_labes 2015-07-02 09:19
- Bloody partial replicate again Helmut 2015-07-02 13:20
- Bloody partial replicate again Lucas 2015-07-02 13:35
- Which model? Helmut 2015-07-02 16:41
- Which model? Lucas 2015-07-02 18:06
- Which model? Helmut 2015-07-02 16:41
- Bloody partial replicate again Lucas 2015-07-02 13:35
- HC Proposed Policy on Bioequivalence Standards for HVDS drgunasakaran1 2015-07-02 17:08
- AUC and Cmax Helmut 2015-07-02 17:37
- HC for HVDs d_labes 2015-07-03 08:21
- HC for HVDs Helmut 2015-07-03 11:55
- Rounding d_labes 2015-07-03 12:53
- Acceptable difference (BE history) Helmut 2015-07-03 14:49
- Off topicElMaestro 2015-07-03 13:02
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 15:38
- Playing around with α (not exactly brilliant) ElMaestro 2015-07-03 16:35
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 16:44
- OT – Philosophers on duty d_labes 2015-07-03 21:11
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 16:44
- Playing around with α (not exactly brilliant) ElMaestro 2015-07-03 16:35
- Playing around with α (not exactly brilliant) Helmut 2015-07-03 15:38
- Rounding d_labes 2015-07-03 12:53
- HC for HVDs Helmut 2015-07-03 11:55
