Bioequivalence and Bioavailability Forum • Bloody partial replicate again

Bloody partial replicate again [Regulatives / Guidelines]

posted by Lucas – Brazil, 2015-07-02 15:35 (3511 d 08:52 ago) – Posting: # 15019
Views: 8,953

Hello my friends

❝ Why the heck:[...]

Yes! I do not like partial replicate designs also. I have a feeling that, taking those converging problems aside, having 2x more data of one treatment than the other is not good for the estimations. Seems like you give more chances for one treatment to show its "real PK profile". Could I say that?

Thx for the link.

Lucas

Complete thread:

HC Proposed Policy on Bioequivalence Standards for HVDS balakotu 2015-07-02 09:05 [Regulatives / Guidelines]
- HC Proposed Policy on Bioequivalence Standards for HVDS d_labes 2015-07-02 09:19
- Bloody partial replicate again Helmut 2015-07-02 13:20
  - Bloody partial replicate againLucas 2015-07-02 13:35
    - Which model? Helmut 2015-07-02 16:41
      - Which model? Lucas 2015-07-02 18:06
- HC Proposed Policy on Bioequivalence Standards for HVDS drgunasakaran1 2015-07-02 17:08
  - AUC and Cmax Helmut 2015-07-02 17:37
- HC for HVDs d_labes 2015-07-03 08:21
  - HC for HVDs Helmut 2015-07-03 11:55
    - Rounding d_labes 2015-07-03 12:53
      - Acceptable difference (BE history) Helmut 2015-07-03 14:49
    - Off topic ElMaestro 2015-07-03 13:02
      - Playing around with α (not exactly brilliant) Helmut 2015-07-03 15:38
        
        Playing around with α (not exactly brilliant) ElMaestro 2015-07-03 16:35
        
        Playing around with α (not exactly brilliant) Helmut 2015-07-03 16:44
        
        OT – Philosophers on duty d_labes 2015-07-03 21:11