Bioequivalence and Bioavailability Forum

CVs (R, T) from pooled CV [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2015-07-02 11:09 (3451 d 20:13 ago) – Posting: # 15014
Views: 30,218

Dear Helmut!

❝ library(PowerTOST)

❝ CV <- 0.07

❝ sep2s <- function(CV, ratio=1) { # split CV to s-ratio

❝   sp  <- CV2mse(CV) # pooled s²

❝   # (1) (s²T + s²R)/2 = s²

❝   # (2) sT/sR = ratio

❝   # solve (1+2) for sT, sR

❝   swt <- sqrt(2)*sqrt(sp)*ratio/sqrt(ratio^2+1)

❝   swr <- sqrt(2)*sqrt(sp)/sqrt(ratio^2+1)

❝   r   <- se2CV(c(swt, swr))

❝   return(r)

❝ } ...

Sometimes it would be helpful to RTFM .
Try
library(PowerTOST)
?CVp2CV.

Note that the ratio is here the ratio of variances.

Complete thread:

• 3 period full repli­cate Dr_Dan 2015-06-24 13:55 [RSABE / ABEL] 
  • 3 period full replicate ElMaestro 2015-06-24 14:11
  • 3 period full replicate Helmut 2015-06-24 14:29
  • 3 period full replicate d_labes 2015-06-24 14:38
    • 3 period full replicate Dr_Dan 2015-06-24 16:43
      • 3 period full replicate Helmut 2015-06-24 18:00
        • 3 period full replicate ElMaestro 2015-06-24 18:11
          • 3 period full replicate Helmut 2015-06-24 18:25
            • 3 period full replicate d_labes 2015-06-25 08:52
              • 3 period full replicate ElMaestro 2015-06-25 10:37
                • OT d_labes 2015-06-25 11:20
                  • OT ElMaestro 2015-06-25 11:54
                    • OT d_labes 2015-06-25 13:51
      • CVs (borderline OT) Helmut 2015-06-26 13:51
        • CVs (R, T) from pooled CVd_labes 2015-07-02 09:09
          • Answering an un­asked ques­tion Helmut 2015-07-02 13:03
            • Answer to an un­asked answer d_labes 2015-07-02 14:21
              • Bloody typo! Helmut 2015-07-02 14:33
        • CVs (borderline OT) zizou 2015-07-05 19:20
          • Degrees of freedom 3-period full replicate d_labes 2015-07-06 11:10
            • Degrees of freedom 3-period full replicate ElMaestro 2015-07-06 11:59
              • Degrees of freedom 3-period full replicate d_labes 2015-07-06 13:53
            • Degrees of freedom 3-period full replicate zizou 2015-07-06 17:25
  • The almighty oracle has spoken! Helmut 2015-07-23 23:54
    • Almighty oracle's mysterious saying d_labes 2015-07-24 08:23