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Register3 period full replicate [RSABE / ABEL]
Dear Detlew
I think the question is whether a replication in only half of ntotal is sufficient in order to scale or ???
With regard to ElMaestro's reply: in a former statement the "leading European regulatory authority" had no problem with full replicate design (=4 periods and 6 possible sequences) and half replicate designs (3 periods and 3 sequences). A full replicate 3-period design would not work according to their argumentation since a 3 period design implicity needs 3 sequences.
I do not know why. Maybe you have an idea?
Kind regards
Dr_Dan
❝ The full replicate 3-period design has the sequences TRT / RTR as is stated in your post and of course has T and R replicated. Not in each subject, but if balanced in half of ntotal each. And this design of course allows the evaluation of the intra-subject variabilities of T and R separately.
I think the question is whether a replication in only half of ntotal is sufficient in order to scale or ???
❝ So what's the problem of the "leading European regulatory authority"?
❝ Especially in the light of ElMaestro's remark that only the intra-subject variability of R is of any regulatory concern if scaled ABE is aimed for 
.
With regard to ElMaestro's reply: in a former statement the "leading European regulatory authority" had no problem with full replicate design (=4 periods and 6 possible sequences) and half replicate designs (3 periods and 3 sequences). A full replicate 3-period design would not work according to their argumentation since a 3 period design implicity needs 3 sequences.
I do not know why. Maybe you have an idea?
Kind regards
Dr_Dan
—
Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- 3 period full replicate Dr_Dan 2015-06-24 13:55 [RSABE / ABEL]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 3 period full replicate ElMaestro 2015-06-24 14:11
- 3 period full replicate Helmut 2015-06-24 14:29
- 3 period full replicate d_labes 2015-06-24 14:38
- 3 period full replicateDr_Dan 2015-06-24 16:43
- 3 period full replicate Helmut 2015-06-24 18:00
- 3 period full replicate ElMaestro 2015-06-24 18:11
- 3 period full replicate Helmut 2015-06-24 18:25
- 3 period full replicate d_labes 2015-06-25 08:52
- 3 period full replicate ElMaestro 2015-06-25 10:37
- 3 period full replicate d_labes 2015-06-25 08:52
- 3 period full replicate Helmut 2015-06-24 18:25
- 3 period full replicate ElMaestro 2015-06-24 18:11
- CVs (borderline OT) Helmut 2015-06-26 13:51
- CVs (R, T) from pooled CV d_labes 2015-07-02 09:09
- Answering an unasked question Helmut 2015-07-02 13:03
- Answer to an unasked answer d_labes 2015-07-02 14:21
- Bloody typo! Helmut 2015-07-02 14:33
- Answer to an unasked answer d_labes 2015-07-02 14:21
- Answering an unasked question Helmut 2015-07-02 13:03
- CVs (borderline OT) zizou 2015-07-05 19:20
- Degrees of freedom 3-period full replicate d_labes 2015-07-06 11:10
- Degrees of freedom 3-period full replicate ElMaestro 2015-07-06 11:59
- Degrees of freedom 3-period full replicate d_labes 2015-07-06 13:53
- Degrees of freedom 3-period full replicate zizou 2015-07-06 17:25
- Degrees of freedom 3-period full replicate ElMaestro 2015-07-06 11:59
- Degrees of freedom 3-period full replicate d_labes 2015-07-06 11:10
- CVs (R, T) from pooled CV d_labes 2015-07-02 09:09
- 3 period full replicate Helmut 2015-06-24 18:00
- 3 period full replicateDr_Dan 2015-06-24 16:43
- The almighty oracle has spoken! Helmut 2015-07-23 23:54
- Almighty oracle's mysterious saying d_labes 2015-07-24 08:23
Ing. Helmut Schütz