Bioequivalence and Bioavailability Forum

SAS code for 3-period, partial-replicated crossover study [RSABE / ABEL]

posted by ElMaestro – Denmark, 2015-06-15 15:46 (3570 d 23:14 ago) – Posting: # 14960
Views: 7,017

Hi MGR,

❝ One of my sponsor asked to do a Partial replicate study, in which there are two tests and one reference. What will be the possible sequences used in the study?

It would be permutations of T₁T₂RR.
It does not sound right to me, intuition and such, but it is definitely possible. 4 periods.

If you insist on 3 periods, I wonder if you could do Perm(RRT₁) and Perm(RRT₂). Three periods, 6 sequences.... rubbish? Some subjects would not be exposed to both Tests I guess. Naw, this sounds too weird too for my taste buds.

—
Pass or fail!
ElMaestro

Complete thread:

SAS code for 3-period, partial-replicated crossover study scorp2011 2015-06-15 12:36 [RSABE / ABEL]
- SAS code for 3-period, partial-replicated crossover study d_labes 2015-06-15 13:24
  - SAS code for 3-period, partial-replicated crossover study MGR 2015-06-15 13:34
    - SAS code for 3-period, partial-replicated crossover studyElMaestro 2015-06-15 13:46
      - Partial-replicated crossover study with 2 Tests d_labes 2015-06-15 14:50

SAS code for 3-period, partial-replicated cross­over study [RSABE / ABEL]

Complete thread:

SAS code for 3-period, partial-replicated crossover study [RSABE / ABEL]