Bioequivalence and Bioavailability Forum • ANOVA F-test results and regulators

ANOVA F-test results and regulators [🇷 for BE/BA]

posted by d_labes – Berlin, Germany, 2015-06-12 17:23 (3571 d 11:57 ago) – Posting: # 14950
Views: 14,206

Dear Helmut,

❝ ...

❝ ❝ But regulators like to see some sort of effect tests in the ANOVA ...

❝

❝ ... I never gave anything but the PE and CI in the main text of my reports (the complete evaluation only in the appendix).

Here we are two, or more than 2 :cool:

❝ Although some assessors or inspectors routinely recalculate studies (in SAS or in the semi-secret WinBE?) I never received a question. Maybe they compared only the CI, which – as you said – is the only relevant part.

May I call you Felix the Fortunate, the Happy? :-D

We received then and when (not so seldom!) questions about the ANOVA F-test results. Up to the request to comment significant results even for the treatment effects, of no relevance in case of BE studies of course.
Nasty the requests to comment the "validity" of the BE evaluation if period and/or sequence effects are found significant. As they many times come out if Type I tests will be applied, especially for sequence.

—
Regards,

Detlew

Complete thread:

R code for lm.mod does not make sense dmfisher 2015-06-09 03:55 [🇷 for BE/BA]
- R code for lm.mod does not make sense yjlee168 2015-06-09 17:57
  - R code for lm.mod does not make sense ElMaestro 2015-06-09 21:07
    - R code for lm.mod does not make sense yjlee168 2015-06-10 11:34
      - R code for lm.mod does not make sense ElMaestro 2015-06-10 14:22
        
        R code for lm.mod does not make sense yjlee168 2015-06-11 09:44
        
        Reference datasets Helmut 2015-06-11 11:50
        
        Reference datasets ElMaestro 2015-06-11 12:01
        
        Reference datasets yjlee168 2015-06-11 22:16
        Type III kuddel muddel d_labes 2015-06-12 09:04
        
        Type III kuddel muddel Helmut 2015-06-12 11:27
        
        ANOVA F-test results and regulatorsd_labes 2015-06-12 15:23
        
        ANOVA F-test results and regulators ElMaestro 2015-06-12 15:29
        
        ANOVA F-test results and regulators d_labes 2015-06-12 15:44
        
        ANOVA F-test results and regulators ElMaestro 2015-06-12 15:52
        
        Type III again ElMaestro 2015-06-12 12:18
        
        SAS OT d_labes 2015-06-12 15:32
        
        Reference datasets yjlee168 2015-06-11 19:56
        Test hypothesis of using Type I/III MS... yjlee168 2015-06-12 09:01
  - R code for lm.mod does not make sense dmfisher 2015-06-10 01:38