Type III kuddel muddel [🇷 for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2015-06-12 13:27 (3529 d 05:20 ago) – Posting: # 14948
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Dear Detlew & all,

❝ WinNonlin/Phoenix uses a different form of F-Tests (not based on Type III sos) AFAIK.


Yes. An excerpt of the manual here and an example there. There is no guaran­tee that Phoenix/WinNonlin and SAS will be that close in all cases.

❝ So what can we suggest to Yung-jin w.r.t. the ANOVA?

❝ SAS way, Phoenix way, R's drop1() (which doesn't work for sequence) or what else?


Duno. We explored package lsmeans in this lengthy thread without a final con­clusion. For the R-com­mu­nity’s “dogma” see Venables’ paper* (section 5).

❝ […] the primary concern, the 90% CI as bioequivalence measure doesn't depend in any way from such considerations. Thank goodness!


:ok:

❝ But regulators like to see some sort of effect tests in the ANOVA. Which one is their secret


I would rather say “[…] by which software and/or coding is their secret”. I never gave anything but the PE and CI in the main text of my reports (the complete eva­lu­ation only in the appendix). Although some assessors or inspectors routinely re­cal­cu­late studies (in SAS or in the semi-secret WinBE?) I never received a ques­tion. Maybe they compared only the CI, which – as you said – is the only relevant part.

When it comes to the type III stuff I gather that it will be practically impossible (e.g., Phoenix/WinNonlin) or difficult (R?) to exactly reproduce SAS’ results. AFAIK only SPSS uses the same algo as SAS.



PS: Kuddelmuddel ~ hash, jumble, mess…


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