Type III kuddel muddel [🇷 for BE/BA]

posted by d_labes  – Berlin, Germany, 2015-06-12 11:04 (3527 d 22:38 ago) – Posting: # 14947
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Dear Helmut, dear ÖbersterGrößterMeister, dear Yung-jin,

❝ ❝ There is no need to “validate” software against SAS. I’ve sent you our papers and the crossover reference datasets on April 17th. ;-)


❝ And in addition, I believe the code that is available online as supplementary material to those papers may be useful for the purpose of producing type III SS anovas.


Do you remember that we have deliberately decided not to deal with the question(s) of Type I, Type III or whatever Type of sum of squares in our papers?

Do you remember also that the SAS Type III sum of squares may not exactly reproduced in R out of the box? We had a lot of discussions here in the forum about that topic.

WinNonlin/Phoenix uses a different form of F-Tests (not based on Type III sos) AFAIK.

So what can we suggest to Yung-jin w.r.t. the ANOVA?
SAS way, Phoenix way, R's drop1() (which doesn't work for sequence) or what else?

The attempt a well-known gangsta has done in the online supplementary material / code w.r.t. Type III sum of squares is not validated (against whatever, preferably SAS :-D since it was invented by the guys at SAS) and may prove as totally in error (except for balanced designs where it is sufficient to change only the header from Type I to Type III :cool:).

Ok, the whole kuddel muddel is only a side scene since the primary concern, the 90% CI as bioequivalence measure doesn't depend in any way from such considerations. Thank goodness!
But regulators like to see some sort of effect tests in the ANOVA. Which one is their secret

Regards,

Detlew

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