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RegisterInterpolate? [PK / PD]
posted by Helmut 
– Vienna, Austria, 2015-06-08 16:02 (3617 d 16:13 ago) – Posting: # 14927
Views: 8,467
Dear Detlew!
Do you remember this thread?
I’m not sure which data were originally presented. From the wording in the EPAR I guess that the applicant set BQLs between two measurable samples to LLOQ/2. Duno what they have done with the first BLQ in the elimination. Some people set this value to LLOQ/2 as well.
❝ Using 0 (zero) instead for that BLOQ?
Do you remember this thread?
❝ Or exclude (the text names exclusion of data)?
I’m not sure which data were originally presented. From the wording in the EPAR I guess that the applicant set BQLs between two measurable samples to LLOQ/2. Duno what they have done with the first BLQ in the elimination. Some people set this value to LLOQ/2 as well.
- I would never ever use LLOQ/2 in the elimination.
- “Embedded BQLs” (© Simon Davis) are a topic of endless debates. Personally I use the lin-up / log-down trapezoidal (which interpolates). Luckily I never saw embedded BQL in my studies for years.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- LLOQ/2 for BQLs not suggested Helmut 2015-06-08 12:35 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Zero suggested? d_labes 2015-06-08 13:31
- Interpolate?Helmut 2015-06-08 14:02
- Impute? ElMaestro 2015-06-08 14:37
- "embedded BLOQ" aka "triangular points" d_labes 2015-06-08 14:51
- Interpolate?Helmut 2015-06-08 14:02
- Zero suggested? d_labes 2015-06-08 13:31
Ing. Helmut Schütz