Pharmacokinetics linearity [Regulatives / Guidelines]
Hi both,
I guess this means never extrapolate, only interpolate? Bioanalysts will yay this proposal
I don't like the "lndose vs lnAUC" thing; it sounds a bit wrong. It must be AUC as function of dose -without logs- that gives a straight line through origo. Anyways, (0,0) is usually the most accurately known point on the entire curve.
❝ ❝ 3. If Cmax and AUC data are available for the dose 25 mg and 50mg and lndose vs lnAUC pass through 0 can linearity be assumed for 5 mg also?
❝
❝ OMG! General principles of linear regression: Never extrapolate beyond your data range actually measured.
I guess this means never extrapolate, only interpolate? Bioanalysts will yay this proposal

I don't like the "lndose vs lnAUC" thing; it sounds a bit wrong. It must be AUC as function of dose -without logs- that gives a straight line through origo. Anyways, (0,0) is usually the most accurately known point on the entire curve.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Pharmacokinetics linearity pjs 2015-05-20 10:25 [Regulatives / Guidelines]
- Pharmacokinetics linearity pjs 2015-05-28 12:26
- Pharmacokinetics linearity nobody 2015-05-28 13:44
- Pharmacokinetics linearityElMaestro 2015-05-28 14:14
- Pharmacokinetics linearity Dr_Dan 2015-05-28 14:32
- Pharmacokinetics linearity pjs 2015-05-28 14:58
- Pharmacokinetics linearity nobody 2015-05-28 15:50
- Pharmacokinetics linearity pjs 2015-05-28 16:11
- Pharmacokinetics linearity Dr_Dan 2015-05-29 09:03
- Pharmacokinetics linearity pjs 2015-05-28 16:11
- Pharmacokinetics linearity nobody 2015-05-28 15:50
- Pharmacokinetics linearity pjs 2015-05-28 14:58
- Pharmacokinetics linearity Dr_Dan 2015-05-28 14:32
- Pharmacokinetics linearityElMaestro 2015-05-28 14:14
- Pharmacokinetics linearity nobody 2015-05-28 13:44
- Pharmacokinetics linearity pjs 2015-05-28 12:26