TSD subjects participation in both stages [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2015-05-12 19:22 (3559 d 12:38 ago) – Posting: # 14796
Views: 5,304

Hi Dr_Dan,

apart from what Helmut said, I'd like to add that unless we somehow fix sample size at stage 2 so that it is equal to sample size at stage 1 we could have subjects for whom there is data for one stage and subjects for whom there is data from two stages. This is complicated to handle from a covariance perspective.
And if we fix sample size at stage 2 so that it equals sample size at stage 1 then my gut feeling tells me that we might too easily get a low power cf. futility rules for ordinary two-stage designs.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,376 posts in 4,912 threads, 1,667 registered users;
187 visitors (0 registered, 187 guests [including 11 identified bots]).
Forum time: 07:01 CET (Europe/Vienna)

The great tragedy of Science – the slaying
of a beautiful hypothesis by an ugly fact.    Thomas Henry Huxley

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5