TSD subjects participation in both stages [Two-Stage / GS Designs]
Hi Dr_Dan,
apart from what Helmut said, I'd like to add that unless we somehow fix sample size at stage 2 so that it is equal to sample size at stage 1 we could have subjects for whom there is data for one stage and subjects for whom there is data from two stages. This is complicated to handle from a covariance perspective.
And if we fix sample size at stage 2 so that it equals sample size at stage 1 then my gut feeling tells me that we might too easily get a low power cf. futility rules for ordinary two-stage designs.
apart from what Helmut said, I'd like to add that unless we somehow fix sample size at stage 2 so that it is equal to sample size at stage 1 we could have subjects for whom there is data for one stage and subjects for whom there is data from two stages. This is complicated to handle from a covariance perspective.
And if we fix sample size at stage 2 so that it equals sample size at stage 1 then my gut feeling tells me that we might too easily get a low power cf. futility rules for ordinary two-stage designs.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- TSD subjects participation in both stages Dr_Dan 2015-05-12 16:35 [Two-Stage / GS Designs]
- Interesting idea! Helmut 2015-05-12 17:05
- Interesting idea! Dr_Dan 2015-05-12 18:11
- TSD subjects participation in both stagesElMaestro 2015-05-12 17:22
- TSD subjects participation in both stages - ANOVA d_labes 2015-05-13 09:33
- Interesting idea! Helmut 2015-05-12 17:05