PK linearity of propranolol [PK / PD]

posted by Dr_Dan  – Germany, 2015-05-11 19:30 (3567 d 16:42 ago) – Posting: # 14786
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Dear PJS
Propranolol is almost completely absorbed after oral administration. However, it undergoes high first-pass metabolism by the liver and on average only about 25% of propranolol reaches the systemic circulation. Propranolol is a substrate for the intestinal efflux transporter, P-glycoprotein (P-gp). However, studies suggest that P-gp is not dose-limiting for intestinal absorption of propranolol in the usual therapeutic dose range.
I hope this helps
Kind regards
Dr_Dan

Kind regards and have a nice day
Dr_Dan

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