Bioequivalence and Bioavailability Forum • Dataset

Dataset [🇷 for BE/BA]

posted by Helmut – Vienna, Austria, 2015-04-18 15:30 (3716 d 07:05 ago) – Posting: # 14700
Views: 29,682

Dear Yung-jin,

❝ do we use the same dataset? :confused:

I’m using bear’s SingleRep_stat_demo.csv (to confirm my numbers see above). I worked with the raw-data and made the log-transformation internally in full precision.
In the dataset lnCmax is given with two decimal figures. If I use those I get R 7.3261, T 7.3900, PE 0.0639.

Seems that there are also some rounding issues in part of the data:

subj drug seq prd Cmax lnCmax round(log(Cmax), 2) 

1     1    2   3  1700   7.43   7.44

2     1    1   4  1461   7.28   7.29

3     1    2   3  1790   7.48   7.49

4     2    1   3  1619   7.38   7.39

4     1    1   4  1364   7.21   7.22

6     1    1   4  1746   7.46   7.47

8     1    1   4  1949   7.57   7.58

9     2    2   4  1769   7.47   7.48

10    2    1   3  1493   7.30   7.31

11    1    2   3  1117   7.01   7.02

12    2    1   3  1257   7.13   7.14

13    1    2   3  1245   7.12   7.13

13    2    2   4  1615   7.38   7.39

… leading to R 7.3289, T 7.3918, PE 0.0629.

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Complete thread:

Reproducing Bear results in Phoenix mittyri 2015-04-14 08:35 [🇷 for BE/BA]
- Bug in bear? Helmut 2015-04-14 14:07
  - Bug in bear? mittyri 2015-04-14 20:43
    - Bug in bear? Helmut 2015-04-15 02:17
  - use the same dataset? yjlee168 2015-04-20 10:13
- Bugs in bear with replicated demo data set? yjlee168 2015-04-15 09:38
- Bugs fixed in bear? yjlee168 2015-04-17 01:21
  - Bugs fixed in bear? Helmut 2015-04-17 14:25
    - Bugs fixed in bear? yjlee168 2015-04-17 18:50
      - Bugs fixed in bear? ElMaestro 2015-04-17 23:14
        
        lme() in bear yjlee168 2015-04-18 11:12
        
        lme() in bear ElMaestro 2015-04-18 11:28
        
        lme() in bear yjlee168 2015-04-18 12:02
        
        lme() in bear ElMaestro 2015-04-18 13:42
        
        Mean means Helmut 2015-04-18 14:08
        
        Mean means ElMaestro 2015-04-18 16:01
        
        Mean means Helmut 2015-04-19 00:59
        
        Mean means ElMaestro 2015-04-19 09:14
        
        LL and AIC Helmut 2015-04-19 11:08
        
        Confused ElMaestro 2015-04-19 11:42
        
        lsmeans for mixed model in R yjlee168 2015-04-19 23:36
        
        lsmeans() & lme() Helmut 2015-04-20 01:28
        
        lsmeans() & lme() yjlee168 2015-04-20 10:23
        lsmeans() & lme() ElMaestro 2015-04-20 10:35
        
        keep it simple! Helmut 2015-04-20 14:34
        
        keep it simple! ElMaestro 2015-04-20 15:39
        
        ML vs. REML Helmut 2015-04-20 16:35
        
        lme() with NA in R yjlee168 2015-04-19 23:44
      - DatasetHelmut 2015-04-18 13:30
        
        Dataset and lme() in bear yjlee168 2015-04-18 23:14