Bioequivalence and Bioavailability Forum • Bugs fixed in bear?

Bugs fixed in bear? [🇷 for BE/BA]

posted by Helmut – Vienna, Austria, 2015-04-17 16:25 (4078 d 16:39 ago) – Posting: # 14694
Views: 33,357

Dear Yung-jin,

❝ … SAS (PROC MIXED) or WNL (same as SAS?) …

PHX/WNL uses a mixed-effects model with REML. In Proc Mixed you can get ML as well.

❝ • […] The correct one should be

❝

❝ Dependent Variable: log(Cmax)

❝ --------------------------------------

❝ MEAN-ref = 7.326071

❝ MEAN-test = 7.39

❝ SE = 0.04758714

❝ Estimate(test-ref) = 0.06373952

Hhm. I got R 7.32814, T 7.39188, PE 0.0637395 (PHX + manual) and SE 0.0475893 (PHX). Both bear’s R and T are shifted –0.03% compared to PHX/manual. Seems that the PE is correct, but how is it calculated from the means? IMHO 7.39 – 7.326071 = 0.063929 ≠ 0.06373952.

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Complete thread:

Reproducing Bear results in Phoenix mittyri 2015-04-14 08:35 [🇷 for BE/BA]
- Bug in bear? Helmut 2015-04-14 14:07
  - Bug in bear? mittyri 2015-04-14 20:43
    - Bug in bear? Helmut 2015-04-15 02:17
  - use the same dataset? yjlee168 2015-04-20 10:13
- Bugs in bear with replicated demo data set? yjlee168 2015-04-15 09:38
- Bugs fixed in bear? yjlee168 2015-04-17 01:21
  - Bugs fixed in bear?Helmut 2015-04-17 14:25
    - Bugs fixed in bear? yjlee168 2015-04-17 18:50
      - Bugs fixed in bear? ElMaestro 2015-04-17 23:14
        
        lme() in bear yjlee168 2015-04-18 11:12
        
        lme() in bear ElMaestro 2015-04-18 11:28
        
        lme() in bear yjlee168 2015-04-18 12:02
        
        lme() in bear ElMaestro 2015-04-18 13:42
        
        Mean means Helmut 2015-04-18 14:08
        
        Mean means ElMaestro 2015-04-18 16:01
        
        Mean means Helmut 2015-04-19 00:59
        
        Mean means ElMaestro 2015-04-19 09:14
        
        LL and AIC Helmut 2015-04-19 11:08
        
        Confused ElMaestro 2015-04-19 11:42
        
        lsmeans for mixed model in R yjlee168 2015-04-19 23:36
        
        lsmeans() & lme() Helmut 2015-04-20 01:28
        
        lsmeans() & lme() yjlee168 2015-04-20 10:23
        lsmeans() & lme() ElMaestro 2015-04-20 10:35
        
        keep it simple! Helmut 2015-04-20 14:34
        
        keep it simple! ElMaestro 2015-04-20 15:39
        
        ML vs. REML Helmut 2015-04-20 16:35
        
        lme() with NA in R yjlee168 2015-04-19 23:44
      - Dataset Helmut 2015-04-18 13:30
        
        Dataset and lme() in bear yjlee168 2015-04-18 23:14