Bioequivalence and Bioavailability Forum • Bugs in bear with replicated demo data set?

Bugs in bear with replicated demo data set? [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2015-04-15 11:38 (3719 d 16:00 ago) – Posting: # 14691
Views: 30,242

Dear mittyri and Helmut,

Thanks for reporting the errors of bear. Please allow me to quickly respond all your questions first.

data source of replicated BE study for demo used in bear: yes, it's indeed artificial data set generated from a 2x2x2 study; however the data set for 2x2x2 study is real. That's because we do not have real data to test. Some users previously suggest that the data set from textbooks or literature can be used instead. But I am sure that we have validated the results manually with MS-excel for some steps only (not all steps; we have many discussions about the differences of SAS and R about dealing linear mixed model in this forum.) Very sorry about this.
differences between WNL and bear as OP mentioned: I will check the codes and update history again and will report what I find here asap.
error in Fdata[[1]] : subscript out of bounds: Helmut, may I have your data file to try for this error? Never see that error before.

Please let me know if I still miss anything for this thread.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Thread locked

Complete thread:

Reproducing Bear results in Phoenix mittyri 2015-04-14 08:35 [🇷 for BE/BA]
- Bug in bear? Helmut 2015-04-14 14:07
  - Bug in bear? mittyri 2015-04-14 20:43
    - Bug in bear? Helmut 2015-04-15 02:17
  - use the same dataset? yjlee168 2015-04-20 10:13
- Bugs in bear with replicated demo data set?yjlee168 2015-04-15 09:38
- Bugs fixed in bear? yjlee168 2015-04-17 01:21
  - Bugs fixed in bear? Helmut 2015-04-17 14:25
    - Bugs fixed in bear? yjlee168 2015-04-17 18:50
      - Bugs fixed in bear? ElMaestro 2015-04-17 23:14
        
        lme() in bear yjlee168 2015-04-18 11:12
        
        lme() in bear ElMaestro 2015-04-18 11:28
        
        lme() in bear yjlee168 2015-04-18 12:02
        
        lme() in bear ElMaestro 2015-04-18 13:42
        
        Mean means Helmut 2015-04-18 14:08
        
        Mean means ElMaestro 2015-04-18 16:01
        
        Mean means Helmut 2015-04-19 00:59
        
        Mean means ElMaestro 2015-04-19 09:14
        
        LL and AIC Helmut 2015-04-19 11:08
        
        Confused ElMaestro 2015-04-19 11:42
        
        lsmeans for mixed model in R yjlee168 2015-04-19 23:36
        
        lsmeans() & lme() Helmut 2015-04-20 01:28
        
        lsmeans() & lme() yjlee168 2015-04-20 10:23
        lsmeans() & lme() ElMaestro 2015-04-20 10:35
        
        keep it simple! Helmut 2015-04-20 14:34
        
        keep it simple! ElMaestro 2015-04-20 15:39
        
        ML vs. REML Helmut 2015-04-20 16:35
        
        lme() with NA in R yjlee168 2015-04-19 23:44
      - Dataset Helmut 2015-04-18 13:30
        
        Dataset and lme() in bear yjlee168 2015-04-18 23:14