Bioequivalence and Bioavailability Forum • Bug in bear?

Bug in bear? [🇷 for BE/BA]

posted by Helmut – Vienna, Austria, 2015-04-15 04:17 (3720 d 07:27 ago) – Posting: # 14689
Views: 30,244

Доброе Утро!

❝ No validation was performed for replicate design?

Duno.

❝ I know that some companies use Bear for BE estimation during the registration procedure. No statistical validation after installation?

To quote myself:

“The ultimate responsibility [for the validation] in a controlled environ-
ment lies in the user’s hands.”

I tried EMA’s (full replicate) Data Set I in bear. I recoded DATA to Cmax and logDATA to lnCmax. Kept columns AUC0t, AUC0INF, lnAUC0t, and lnAUC0INF (set all cells to NA). The import seems to work. Observations: AUC0t, AUC0INF, lnAUC0t, and lnAUC0INF are converted to character variables with empty cells. I had to change the variable type to “numeric” in order to get the NAs back. However, after closing the data editor bear told me:

<0 rows> (or 0-length row.names)

Error in Fdata[[1]] : subscript out of bounds

I suspected issues with incomplete subjects. Deleted subjects 11, 20, 24, 31, 42, 67, 69, 71. Same error.
I guess we have to wait until Yung-jin passes by. ;-)

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

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Complete thread:

Reproducing Bear results in Phoenix mittyri 2015-04-14 08:35 [🇷 for BE/BA]
- Bug in bear? Helmut 2015-04-14 14:07
  - Bug in bear? mittyri 2015-04-14 20:43
    - Bug in bear?Helmut 2015-04-15 02:17
  - use the same dataset? yjlee168 2015-04-20 10:13
- Bugs in bear with replicated demo data set? yjlee168 2015-04-15 09:38
- Bugs fixed in bear? yjlee168 2015-04-17 01:21
  - Bugs fixed in bear? Helmut 2015-04-17 14:25
    - Bugs fixed in bear? yjlee168 2015-04-17 18:50
      - Bugs fixed in bear? ElMaestro 2015-04-17 23:14
        
        lme() in bear yjlee168 2015-04-18 11:12
        
        lme() in bear ElMaestro 2015-04-18 11:28
        
        lme() in bear yjlee168 2015-04-18 12:02
        
        lme() in bear ElMaestro 2015-04-18 13:42
        
        Mean means Helmut 2015-04-18 14:08
        
        Mean means ElMaestro 2015-04-18 16:01
        
        Mean means Helmut 2015-04-19 00:59
        
        Mean means ElMaestro 2015-04-19 09:14
        
        LL and AIC Helmut 2015-04-19 11:08
        
        Confused ElMaestro 2015-04-19 11:42
        
        lsmeans for mixed model in R yjlee168 2015-04-19 23:36
        
        lsmeans() & lme() Helmut 2015-04-20 01:28
        
        lsmeans() & lme() yjlee168 2015-04-20 10:23
        lsmeans() & lme() ElMaestro 2015-04-20 10:35
        
        keep it simple! Helmut 2015-04-20 14:34
        
        keep it simple! ElMaestro 2015-04-20 15:39
        
        ML vs. REML Helmut 2015-04-20 16:35
        
        lme() with NA in R yjlee168 2015-04-19 23:44
      - Dataset Helmut 2015-04-18 13:30
        
        Dataset and lme() in bear yjlee168 2015-04-18 23:14