Replicated 4×2 and two-stage-design, in the same pro­to­col [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2015-04-06 08:53 (2637 d 04:58 ago) – Posting: # 14661
Views: 14,971

Hi Mauricio,

» Is it possible? Or I am crazy in front of the statistic and statisticians?:confused:

Combining 2-stage and replicated studies in one protocol is hitherto undescribed in the scientific literature. So you likely do not know how the type I error is controlled or how your method performs in terms of power/sample sizes. If the agency asks you to give proof that the Type I Error is controlled you might be somewhat doomed?

There appears to me to be no reason why it wouldn't work, though. It just needs to be investigated and reported.

Pass or fail!

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